What Is CJC-1295 WITH DAC 2MG?
CJC-1295 DAC is a modified version of growth hormone-releasing hormone, a naturally occurring compound present in the human body. It comprises 29 amino acids with a molecule of DAC attached to the chain with the help of a lysine linker. DAC (drug affinity complex) allows the drug to bind with plasma protein (albumin), thus extending its half-life. It also prevents the metabolism of CJC-1295, further prolonging the duration of action. It has been shown that CJC-1295 DAC has a half-life of 5-8 hours while CJC-1295 with no DAC has a half-life of just 7-8 minutes . Its prolonged duration of action and long half-life make it a subject of interest for researchers to explore the therapeutic potential of growth hormone secretagogues.
Structure Of CJC-1295 WITH DAC 2MG
Molecular Formula: C171H281N49O47
Molecular Weight: 3775.4 g/mol
CAS number: 863288-34-0
CJC-1295 was first synthesized by a Canadian company called ConjuChem Technologies in the mid-2000s in order to develop a better alternative for short-acting injectable growth hormone. It underwent phase II clinical trials for lipodystrophy treatment. However, the research was discontinued because of the death of one participant. Investigators explained that the patient died because he had asymptomatic coronary artery disease. Still, the project was terminated because of precautionary measures.
Mechanism Of CJC-1295 WITH DAC 2MG
CJC-1295 DAC binds to the GHRH receptors in the pituitary gland and stimulates the release of growth hormone. One study found that a single injection of CJC-1295 brought an increase in the release of GH and insulin-like growth factor-1 by 50% .
The use of GHRH analog therapy is an important consideration for the treatment of GH deficiency disorders in individuals with the intact pituitary gland. Research shows that CJC-1295, a long-acting GHRH analog, resembles the physiological pulsatile secretion of growth hormone .
One study was conducted to assess the effect of CJC-1295 in mice with GHRH gene ablation. The subjects were divided into three groups and each received synthetic analog for 5 weeks at intervals of 24, 48 and 72 hours. The results found that the subjects who received daily therapy maintained normal body weight and length. However, the groups who took the drug at intervals of 48 and 72 hours experienced an increase in body weight and length without full growth normalization. These findings suggest that a daily dose of CJC-1295 was able to normalize growth and body composition in GH-deficient mice .
Furthermore, another study determined the pharmacokinetics and safety profile of CJC-1295 DAC. The results found that subcutaneous administration of CJC-1295 DAC increased plasma concentration of GH by 2-3 fold for 6 days and IGF-1 by 1.5-3 fold for 11 days. As a GHRH analog, it has been expected to boost muscle mass, improve athletic performance and enhance recovery. Furthermore, research shows that its use has been found among females for youthful appearance . However, these therapeutic claims are not supported by valid scientific studies and it hasn’t been approved by the FDA yet. At Pinnacle Peptides, CJC-1295 DAC for sale is available for research only.
CJC-1295 DAC is a GHRH analog that stimulates the release of growth hormone. It is composed of 29- amino acids with a molecule of DAC attached to it. Its structure allows for a prolonged duration of action and a long half-life. Research shows that CJC-1295 DAC increases IGF-1 and GH plasma concentration by 50%. Furthermore, it has the potential to treat GH deficiency disorders. Pinnacle Peptide offers CJC-1295 DAC purchase exclusively for research and experimentation. Only buy CJC-1295 DAC if you are an authorized researcher.
- Teichman, S.L., et al., Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults. The Journal of Clinical Endocrinology & Metabolism, 2006. 91(3): p. 799-805.
- Ionescu, M. and L.A. Frohman, Pulsatile secretion of growth hormone (GH) persist during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab, 2006. 91(12): p. 4792-7.
- Alba, M., et al., Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab, 2006. 291(6): p. E1290-4.
- Van Hout, M.C. and E. Hearne, Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions. Subst Use Misuse, 2016. 51(1): p. 73-84.
High Performance Liquid Chromatography (HPLC)
Mass Spectrometry (MS)
What is CJC-1295 DAC?
The synthetic peptide CJC-1295 is available in a modified version called CJC-1295 with DAC (Drug Affinity Complex). It has a longer half-life because it contains DAC, a peptide fragment. This indicates that CJC-1295 with DAC has a longer half-life in the body, enabling prolonged release of growth hormone (GH). It causes the pituitary gland to release growth hormone by attaching to the growth hormone secretagogue receptor. CJC-1295 with DAC is a well-liked option for those wanting prolonged elevation of GH levels due to its extended-release properties, which may have advantages including greater muscle mass, accelerated recovery, and improved fat metabolism.
CJC 1295 with DAC Research
CJC 1295 with DAC (Drug Affinity Complex) has been the subject of scientific research due to its potential role in stimulating growth hormone (GH) release and its extended half-life. Here is an organized overview of the research conducted on CJC 1295 with DAC:
GH Secretion and Stimulation:
The capacity of CJC 1295 with DAC to promote the release of growth hormone has been the subject of studies. CJC 1295 with DAC stimulates growth hormone (GH) production and release from the pituitary gland by attaching to the growth hormone secretagogue receptor. According to research, administering CJC 1295 along with DAC can cause GH levels to rise steadily, potentially boosting a range of physiological consequences related to GH release.
Extended Half-Life and Dosing:
The longer half-life of CJC 1295 with DAC that results from the use of DAC is one of its main benefits. This makes it possible to dose less often than with other peptides. The best dose schedules and intervals for sustaining GH elevation and maximizing the potential advantages of CJC 1295 with DAC have been investigated in research.
Muscle Growth and Recovery:
The potential for CJC 1295 with DAC to promote muscle growth and facilitate recovery has been explored. It may stimulate protein synthesis, nitrogen retention, and insulin-like growth factor-1 (IGF-1) production, all of which are critical for muscle growth, recovery, and repair, according to research.
Studies have looked at how CJC 1295 with DAC affects the metabolism of fat. It has been demonstrated to encourage lipolysis, the breakdown of fat stores, which may help with body composition changes and fat reduction. The combination of CJC 1295 and DAC may improve the use of fats as an energy source, which is good for controlling weight.
Safety and Side Effects:
The safety and potential adverse effects of CJC 1295 with DAC have also been the subject of research. Despite the fact that it is typically tolerated well, studies have noted brief spikes in blood glucose and potential effects on the thyroid axis. Further research is needed to determine the long-term safety and any interactions with other disorders or drugs.
Where to Buy CJC-1295 with DAC
CJC 1295 WITH DAC for sale is available in the purest form only at Pinnacle Peptides. If you are from the field on research and you need this peptide in any amounts, you can get them easily at our website. The quality and prices of their products is unbeatable. You can also purchase CJC 1295 WITH DAC online in bulk as per your requirements. Pinnacle Peptides has been trusted over the years by several scientists and researchers for the purchase of best quality peptides. However it must be pointed out that these peptides at present are available only for medical purposes, not for direct human intake.
The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.