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What Is LIQUICLOMI 50MG / ML | 60ML?

Clomiphene, also known as clomifene, is a selective estrogen receptor modulator (SERM). It is a non-steroidal derivative of triphenylethylene that was first developed by Frank Palopoli in 1956. Later, it was approved by the FDA for the treatment of infertility in women in 1967. It is often prescribed off-label to treat secondary hypogonadism in men. The drug has also been shown to treat and prevent short-lasting unilateral neuralgiform headache attacks (SUNCT). Furthermore, it is banned by the World Anti-Doping Agency as it has been shown to boost athletic performance. At Pinnacle Peptides, liquid clomiphene for sale is exclusively available for research and experimentation.

Structure Of LIQUICLOMI 50MG / ML | 60ML

From Pubchem


IUPAC Name: 2-[4-[(Z)-2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine
Synonyms: Zuclomiphene, Clomifene, Clomid
Molecular Formula: C26H28ClNO
Molecular Weight: 406.0 g/mol
Sequence: Ala-Glu-Asp-Gly
CAS number: 15690-55-8
PubChem CID: 1548955

Mechanism Of LIQUICLOMI 50MG / ML | 60ML

Research shows that clomiphene exerts both estrogenic and antiestrogenic effects depending on the estrogen levels in the body. It binds to estrogen receptors located in the hypothalamus and competitively blocks the effect of naturally occurring hormone. This, in turn, sends the signal to the hypothalamus that estrogen levels are low in the body, As a result, it stimulates increases in the secretion of GnRH (gonadotropin-releasing hormone). GnRH stimulates the ovaries to release FSH and LH, ultimately inducing ovulation [1].

Pre-Clinical/Clinical Research

1. Acromegaly

Acromegaly is a disorder that causes enlargement of the body tissues and organs, such as hands and feet. It is caused by excessive production of growth hormones. Studies indicate that estrogen therapy can show positive results in women with acromegaly. On the other side, SERMs have been shown to treat this disorder in both men and women.

One study was designed to look at the effect of clomiphene citrate on serum IGF-1 and testosterone in men with uncontrolled acromegaly. Six male patients were enrolled in the study and asked to add clomid to their treatment. The researchers observed that treatment successfully enhanced testosterone levels by up to 209% and caused a reduction in IGF-1 levels by 44 %, suggesting the potential of clomiphene to treat acromegaly in men not responding to other therapies [2].

2. Short-lasting Unilateral Neuralgiform Headache Attacks (SUNCT) syndrome

SUNCT is a type of headache disorder characterized by sudden, severe, short-lasting and frequent attacks of pain on the one side of the head. It manifests autonomic symptoms, such as eyelid edema, conjunctivitis injection and nasal congestion. Research shows that clomiphene citrate might prevent or even treat SUNCT. A case report of a patient diagnosed with SUNCT, who was unresponsive to traditional treatment options, reported that clomiphene therapy completely resolved the frequent attacks [3].

3. Infertility

Clomiphene is utilized to induce ovulation in women experiencing irregular ovulation due to conditions like polycystic ovary syndrome (PCOS) or anovulation. It may be prescribed alone or in combination with metformin or other insulin sensitizers.

A comparative study investigated the effectiveness of clomiphene and metformin in women with PCOS. The study involved 626 infertile women with PCOS who were randomly assigned to receive either clomiphene, metformin, or a combination of both. The findings revealed live birth rates of 22.5%, 7.5%, and 26.8% in the clomiphene, metformin, and combination therapy groups, respectively. The study concluded that clomiphene demonstrated superior efficacy compared to metformin [4].

Many patients with PCOS develop resistance to the use of clomiphene citrate. The combination of letrozole and metformin has been shown to be effective for such candidates [5]. Research suggests that letrozole is associated with higher live birth rates and improved ovulation outcomes compared to clomiphene [6]. Additionally, clomiphene has been shown to improve male infertility. Studies indicate that it can enhance sperm production and motility, serving as a safe therapy to improve sperm parameters in infertile men [7].

4. Secondary Hypogonadism

Secondary hypogonadism is a condition in which the testes receive inadequate stimulation from the hypothalamus and pituitary glands. These results in the reduced production of sex hormones and the appearance of symptoms, such as muscle weakness, low libido and erectile dysfunction.

Testosterone replacement therapy (TRT) is used for the treatment of secondary hypogonadism. However, it causes an increase in hematocrit levels and prostate-specific antigen (PSA), limiting its long-term utilization. On the other hand, clomifene has been shown to treat secondary hypogonadism. It stimulates the release of GnRH [8]. One study found that clomiphene can improve testosterone levels by 53.2% as compared to TRT (46.8%) [9].


Clomiphene belongs to the selective estrogen receptor modulators. It has been used for ovulation induction in women who are unable to ovulate regularly. Research shows that it can also improve male infertility, and treat hypogonadism and acromegaly. Furthermore, one case report found that it might resolve frequent headache attacks associated with SUNCT. However, we need more research to confirm this effect. At Pinnacle Peptides, liquid clomid purchase is solely available for research and educational institutions. Only buy clomiphene if you are a licensed researcher.


  1. Mbi Feh MK, Wadhwa R. Clomiphene. [Updated 2022 Jun 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.
  2. Duarte, F.H., R.S. Jallad, and M.D. Bronstein, Clomiphene citrate for treatment of acromegaly not controlled by conventional therapies. J Clin Endocrinol Metab, 2015. 100(5): p. 1863-9.
  3. Rozen, T.D., et al., Clomiphene citrate as a new treatment for SUNCT: hormonal manipulation for hypothalamic-influenced trigeminal autonomic cephalalgias. Headache, 2005. 45(6): p. 754-6.
  4. Legro, R.S., et al., Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome. New England Journal of Medicine, 2007. 356(6): p. 551-566.
  5. Sohrabvand, F., S. Ansari, and M. Bagheri, Efficacy of combined metformin–letrozole in comparison with metformin–clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease. Human Reproduction, 2006. 21(6): p. 1432-1435.
  6. Legro, R.S., et al., Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome. New England Journal of Medicine, 2014. 371(2): p. 119-129.
  7. Huijben, M., et al., Clomiphene citrate for male infertility: A systematic review and meta-analysis. Andrology, 2023. 11(6): p. 987-996.
  8. Huijben, M., et al., Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis. Andrology, 2022. 10(3): p. 451-469.
  9. Garcia-Touza, M., Safety and Efficacy of Clomiphene Citrate in the Treatment of Secondary Hypogonadism. A Retrospective Study. Journal of the Endocrine Society, 2021. 5(Supplement_1): p. A761-A761.

What is Clomiphene?

Clomiphene, also known by its brand name Clomid, is a medication commonly prescribed to treat fertility issues in women. It is a member of the selective estrogen receptor modulators (SERMs) pharmacological class. The mechanism of action of clomiphene is to promote the release of ovulation-inducing hormones. It is primarily utilized by females who undergo assisted reproductive procedures like in vitro fertilization (IVF) or who have irregular or nonexistent menstrual periods. Clomiphene boosts ovulation, which raises the likelihood of getting pregnant. The use of Clomiphene should be reviewed with a healthcare provider to confirm its safety and efficacy, while it may not be appropriate for everyone.

Clomiphene Research

The drug clomiphene, also known by the brand name Clomid, has been extensively studied in a number of medical specialties. This SERM (selective estrogen receptor modulators)-class reproductive medication has drawn interest due to its potential to treat infertility, male hypogonadism, and hormonal imbalances.

Infertility Treatment:

One of the main areas of research on Clomiphene is its application in the management of infertility. Women with anovulation, or irregular or nonexistent menstrual cycles, are frequently prescribed it. In order to induce ovulation, clomiphene stimulates the pituitary gland's secretion of the hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Clomiphene is a crucial component of fertility therapy because studies have demonstrated that it can considerably raise the chances of successful ovulation and subsequent pregnancy.

Assisted Reproductive Techniques:

Research has also been interested in how clomiphene helps assisted reproductive technologies like in vitro fertilization (IVF). Clomiphene may occasionally be combined with other drugs to encourage the formation of numerous follicles and improve the odds of successful IVF outcomes. According to studies, adding Clomiphene to IVF methods may increase the quantity and quality of retrieved eggs, hence raising the procedure's overall success rates.

Male Hypogonadism:

Clomiphene study has looked into its possible advantages in male hypogonadism in addition to its usage in female infertility. Hypogonadism is the term for low testosterone levels, which can cause a number of symptoms like diminished libido, exhaustion, and infertility. Increased levels of luteinizing hormone and follicle-stimulating hormone, which in turn boost testosterone production, are how clomiphene works. Numerous studies have shown that Clomiphene is beneficial in reducing symptoms of male hypogonadism and increasing testosterone levels, making it a possible substitute for testosterone replacement treatment.

Hormonal Disorders:

Studies on the effectiveness of clomiphene in treating several hormonal disorders have been conducted. A common endocrine illness in women called polycystic ovarian syndrome (PCOS) is characterized by hormonal imbalances that can lead to irregular ovulation and infertility. According to studies, Clomiphene can successfully restore ovulation in women with PCOS and increase those women's chances of getting pregnant.

Where to Buy Clomiphene

Pinnacle Peptides is among the most trusted online stores that provides CLOMIPHENE for sale of best quality. These are trusted by thousands of scientists all over the world for carrying out their research. Being scientists and researchers, the team at Pinnacle Peptides understands how important it is to have good quality chemicals and high quality peptides for the research work. We provide a special offer by availing the products at highly competitive rates and yet deliver these products in the purest form possible. If you are looking to buy Clomiphene online for your research then purchase it from our website hassle-free. The products are shipped both to domestic and international destinations with prompt delivery time. Pinnacle Peptides are the producers who have been trusted by several scientists for Clomiphene purchase. Also, there is a variety of other lab supplies and chemicals in stock that might be essential for your work. We strive to have all your research material at a one stop location to provide a hassle-free experience.


The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.

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DISCLAIMER: The products sold on this site are not a drug nor is it intended to treat, diagnose, cure or prevent any disease, nor is it meant for ANY cosmetic purpose. Pinnacle Peptides makes no claims of alleged beneficial properties of any product on this site if injected or ingested in any manner. Our Peptides are exclusively distributed legally within the laws of safe harbor for research peptides and are to be used for that purpose ONLY. If any country’s governing bodies feel we are in violation of their laws regarding peptides, we ask you contact us immediately via [email protected] so we may expeditiously rectify the situation.All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following:Their government regulations regarding the importation, purchase, possession and use of peptides. The health and safety hazards associated with the handling of peptides in a research setting. That peptides are NOT intended to be used as a food additive, drug, vitamin, supplement, cosmetic or any other inappropriate application. Such a sale would be otherwise denied.
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