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The chemicals/materials for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.

What Is IGF-1 LR3 1MG?

IGF-1 LR3 stands for insulin-like growth factor-1 long arginine 3. It is a man-made peptide derivative of insulin-like growth factor-1. It differs from IGF-1 by additional 13 amino acids at the N-terminus and the substitution of arginine with glutamic acid at the 3rd position. These modifications make it approximately 3 times more potent and extend its half-life (20-30 hours) and duration of action. Like IGF-1, it has been shown to promote muscle growth and cell differentiation. At Pinnacle Peptides, IGF-1 LR3 for sale is exclusively available for research and educational purchases.

Structure Of IGF-1 LR3 1MG

From Pubchem


Synonyms: Insulin-like growth factor long chain R3, Long-(arg3)insulin-like growth factor-i
Molecular Formula: C400H625N111O115S9
Molecular Weight: 9117.60 g/mol
CAS number: 143045-27-6
PubChem CID: 381123731

Mechanism Of IGF-1 LR3 1MG

IGF-1 LR3 retains the pharmacological properties of IGF-1 and binds to insulin-like growth factor-1 receptor. This binding triggers the cascade of intracellular events that eventually lead to the activation of the PI3/AKT and MAPT pathways. Activation of these pathways mediates various cellular responses, including protein synthesis, cell differentiation and proliferation in muscle and other cells. Furthermore, IGF-1 LR3 has been shown to inhibit apoptosis. It is important to note that modifications in IGF-1 LR3 contribute to its low affinity to insulin-like growth factor binding proteins (IGFBP), extending its half-life.

Pre-Clinical/Clinical Research

1. Bone Health

IGF-1 deficiency is associated with poor bone health. A cross-sectional study found that low serum levels of IGF-1 are associated with the increase of vertebral fractures among postmenopausal women with type 2 diabetes [1]. On the other hand, a literature review of clinical studies found that the administration of IGF-1 and growth hormone increases bone resorption and bone formation. Moreover, IGF-1 boosts bone healing and increases movement in patients with tibia and hip fractures [2].

2. Muscle Hypertrophy

Insulin-like growth factor-1 is a myostatin inhibitor that prevents muscle breakdown in conditions like muscular dystrophy. Myostatin, also known as growth differentiation factor 8, affects muscle mass by reducing protein synthesis and muscle growth, thus preventing unwanted hypertrophy [3]. Furthermore, IGF-1 stimulates the proliferation of myoblasts, thus causing an increase in muscle cells. IGF-1 LR3 has a more profound effect on hyperplasia as compared to IGF-1 because of its high potency [4].

3. Cognition

IGF-1 has been shown to promote neuroprotection by preventing neuronal loss and stimulating cell survival. One study in old-aged animals found that IGF-1 boosts neurogenesis and increases vascular density in brain areas that are involved in learning and memory [5]. Furthermore, IGF-1 increases excitatory synaptic neurotransmission in the hippocampus by 40%. The scientific literature reveals that increased synaptic transmission might be mediated by AMPA receptors and PI3/Akt pathway [6].

4. Muscle Recovery and Healing

Insulin-like growth factor-1 plays a key role in muscle recovery and repair. A study conducted on mouse model found that administration of recombinant IGF-1 LR3 on days 2, 5, and 7 enhanced muscle healing in injured and strained muscles [7].

Similarly, another study replicated these findings while investigating the impact of IGF-1 on muscle damage in mice. It found that mice treated with IGF-1 showed enhanced muscle regeneration and faster recovery in terms of rapid muscle contractions compared to the control group. Additionally, IGF-1 was linked to an increased number of newly forming muscle fibers at the treated site [8].

Muscle mass and ability to regenerate muscle cells decline with advancing age. Research indicates that IGF-1 treatment in older individuals can help maintain lean muscle mass [9].

5. Diabetes

IGF-1 plays an important role in regulating glucose levels within the body. It interacts with both IGF-1 receptors and insulin receptors, which are responsible for facilitating the uptake of glucose from the bloodstream into liver and muscle cells. This interaction leads to a reduction in blood sugar levels. Scientific studies have revealed that IGF-1 LR3 is associated with a notable enhancement in glucose uptake, resulting in decreased blood glucose levels [10].

In one study, the administration of IGF-1 to rats with diabetic cardiomyopathy produced several beneficial effects, including a reduction in myocardial apoptosis, oxidative stress, inflammation, interstitial fibrosis, and metabolic irregularities. Additionally, it promoted the activation of the Akt/GSK-3β pathway, suggesting that IGF-1 LR3 therapy holds the potential to treat individuals with diabetic heart muscle-related issues [11].


IGF-1 LR3 is a modified potent derivative of insulin-like growth hormone-1. It has a longer half-life and a prolonged duration of action. It has been shown to improve diabetes and promote cardioprotection. It boosts muscle growth, enhances muscle recovery and speeds up healing. Furthermore, it reduces the risk of bone fracture and enhances cognition. However, further research is needed to confirm these effects. We don’t support its unwarranted use and offer IGF-I LR3 purchase only for research and educational purposes. Only buy IGF-1 LR3 if you are a licensed researcher.


  1. Ardawi, M.-S.M., et al., Increased serum sclerostin and decreased serum IGF-1 are associated with vertebral fractures among postmenopausal women with type-2 diabetes. Bone, 2013. 56(2): p. 355-362
  2. Locatelli, V. and V.E. Bianchi, Effect of GH/IGF-1 on Bone Metabolism and Osteoporosis. Int J Endocrinol, 2014. 2014: p. 235060.
  3. Schiaffino, S. and C. Mammucari, Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models. Skelet Muscle, 2011. 1(1): p. 4.
  4. Tomas, F.M., A.B. Lemmey, L.C. Read, and F.J. Ballard, Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection. J Endocrinol, 1996. 150(1): p. 77-84.
  5. Sonntag, W.E., M. Ramsey, and C.S. Carter, Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Research Reviews, 2005. 4(2): p. 195-212.
  6. Ramsey, M.M., et al., Functional Characterization of Des-IGF-1 Action at Excitatory Synapses in the CA1 Region of Rat Hippocampus. Journal of Neurophysiology, 2005. 94(1): p. 247-254..
  7. Laumonier, T. and J. Menetrey, Muscle injuries and strategies for improving their repair. Journal of Experimental Orthopaedics, 2016. 3.
  8. Kasemkijwattana, C., et al., Use of Growth Factors to Improve Muscle Healing After Strain Injury. Clinical Orthopaedics and Related Research®, 2000. 370.
  9. Cappola, A.R., et al., Association of IGF-I levels with muscle strength and mobility in older women. J Clin Endocrinol Metab, 2001. 86(9): p. 4139-46.
  10. Assefa, B., et al., Insulin-Like Growth Factor (IGF) Binding Protein-2, Independently of IGF-1, Induces GLUT-4 Translocation and Glucose Uptake in 3T3-L1 Adipocytes. Oxidative Medicine and Cellular Longevity, 2017. 2017: p. 3035184.
  11. Wang, C.Y., X.D. Li, Z.H. Hao, and D. Xu, Insulin-like growth factor-1 improves diabetic cardiomyopathy through antioxidative and anti-inflammatory processes along with modulation of Akt/GSK-3β signaling in rats. kjpp, 2016. 20(6): p. 613-619.

Certificate of Analysis (COA)


High Performance Liquid Chromatography (HPLC)


Mass Spectrometry (MS)


What is IGF LR3?

IGF-1 LR3, or Insulin-like Growth Factor-1 Long R3, is a modified form of the naturally occurring hormone insulin-like growth factor 1 (IGF-1). Compared to native IGF-1, it has a longer half-life and a higher binding affinity to IGF-1 receptors. IGF-1 LR3 has an extra amino acid sequence that increases its effectiveness and stability. This peptide is well known for its strong anabolic properties, which support tissue healing, protein synthesis, and cell development. In addition to studying growth factor signaling pathways, examining muscle growth and regeneration, and evaluating possible therapeutic uses in situations including growth hormone shortage and muscle wasting disorders, researchers use IGF-1 LR3 in a variety of research areas.

IGF-1 LR3 Research

IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a modified form of the natural hormone insulin-like growth factor 1 (IGF-1). Here are the key areas of IGF-1 LR3 research, highlighting its effects and potential applications.

Enhanced Biological Activity:

The increased biological activity of IGF-1 LR3 in comparison to native IGF-1 is one of the main areas of research in this compound. Growth-promoting pathways can be stimulated for a longer period of time and with greater potency when IGF-1 LR3 is present because it has a longer half-life and greater binding affinity to IGF-1 receptors. To understand how IGF-1 LR3 affects cellular development, proliferation, and tissue healing, researchers have looked at the molecular pathways and signaling cascades that it affects.

Muscle Growth and Regeneration:

The ability of IGF-1 LR3 to encourage muscle growth and repair is well recognized. Increased muscular mass and strength result from its stimulation of protein synthesis and enhancement of muscle cell proliferation. IGF-1 LR3 has been found to enhance muscle regeneration following injuries or demanding exercise. Scientists investigate its role in muscle hypertrophy, muscle wasting conditions, and enhancing athletic performance.

Bone Health and Regeneration:

Research on IGF-1 LR3's effects on bone health and regeneration has looked at these outcomes. According to studies, IGF-1 LR3 is important for the development, mineralization, and control of bone turnover. It increases osteoblast activity, fostering bone remodeling and development. IGF-1 LR3 may be used to treat bone-related conditions like osteoporosis and bone fractures, according to research.

Wound Healing and Tissue Repair:

IGF-1 LR3 has been researched for its potential in tissue repair and wound healing. Studies have demonstrated its capacity to quicken tissue regeneration, boost collagen synthesis, and hasten wound closure. In order to improve post-surgical recovery, promote the healing of chronic wounds, and aid in tissue repair in a variety of medical disorders, researchers are investigating the therapeutic applications of IGF-1 LR3.

Metabolic Effects:

IGF-1 LR3 research has also looked into the effects on metabolism. IGF-1 LR3 has demonstrated potential for enhancing lipid, glucose, and insulin sensitivity. It controls how nutrients are used and the balance of energy. The therapeutic potential of IGF-1 LR3 in the treatment of metabolic diseases like diabetes and obesity is being studied by researchers.

Where to Buy IGF-1 LR3

Pinnacle Peptides is such an trustworthy platform where you can buy IGF-1 LR3 online with the facility of customer support. This facility encourages the buyers to come forward and purchase the genuine samples of this formulation from the website. As you search through the internet you would be able to grab hold of the leading retailers that make IGF-1 LR3 purchase available in bulk for a very low-end price. Despite of the rate differences, one should concentrate in the level of quality too. Compensating on the level of quality of the product for grabbing hold of a low-end priced product would be a waste of money.


The products we offer are intended for laboratory research use only. When you buy peptides online from our website, as a customer you must acknowledges that there are risks involved with consumption or distribution of these products. These chemicals for sale here are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.

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