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The chemicals/materials for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.


Melanotan 2 is a man-made analog of alpha-melanocyte-stimulating hormone (a-MSH), a naturally occurring peptide present in the human body. a-MSH is produced by the pituitary gland that is involved in the process called melanogenesis i.e., stimulates melanocytes to produce melanin that is responsible for the pigmentation of skin.

Structure Of MELANOTAN 2 10MG

From Pubchem


IUPAC Name:(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
Synonyms: Melanotan II, MT-II
Molecular Formula: C50H69N15O9
Molecular Weight:1024.2 g/mol
CAS number: 121062-08-6
PubChem CID: 92432


Melanotan II was developed in the early 1990s at the University of Arizona by by Dr. Victor Hruby and Dr. Mac Hadley. The initial aim of the research was to create a compound that could stimulate melanin production in the skin as a potential treatment for skin conditions like vitiligo, where patients have patches of depigmented skin.

During the research process, one of the scientists injected himself with a high dose of Melanotan II and experienced an eight-hour of erection along with nausea and vomiting. It has gained attention and controversy due to its unregulated use as a skin tanning injection, raising concerns about its potential misuse. It has not been approved for human use, MT-II for sale is restricted for research purposes only.

Mechanism Of MELANOTAN 2 10MG

Melanotan II is a non-selective agonist of melanocortin receptors. There are five types of melanocortin receptors, MC1R, MC@R, MC3R, MC4R and MC5R.

  • MC1 Receptor is located on the melanocytes and its stimulation by MT-II causes darkening of skin and hair.
  • MC2R activation is involved in the secretion of adrenal hormones, like cortisol.
  • MC3R stimulation by MT-II regulates appetite and energy homeostasis.
  • MC4 receptors are mainly involved in sexual arousal and cause changes in feeding behaviour.
  • MC5R can influence sebum production and temperature homeostasis.

Pre-Clinical/Clinical Research

1. Insulin Sensitivity

Studies show that Melanotan-II might be involved in improving insulin sensitivity. A study conducted on rats found that peripheral administration of MT-II can improve glucose tolerance and boost insulin sensitivity [1]. Similarly, intracerebrovascular administration of melanotan-II has been shown to enhance insulin-mediated glucose uptake. Nonetheless, it had no impact on the body's natural glucose production, suggesting that the activation of MC3R and MC4R receptors in the central nervous system affects insulin sensitivity in a tissue-specific manner, independently [2]. However, a recent clinical trial found contradictory results that 10 MT-II administration before bedtime reduced insulin sensitivity by 12% in men [3].

2. Melanoma

UV rays are well-known for their detrimental effects on skin health and their association with the development of skin cancers. They cause inflammation and induce immediate oxidative stress, leading to the production of free radicals that can damage skin cells. Additionally, scientific studies have linked UV rays to the suppression of both local and systemic immune responses. Melatonin, which possesses antioxidant properties and the ability to reduce cell death (apoptosis), offers a potential shield against the harmful effects of UV rays [4]. Furthermore, another study suggests that melanotan II, through the upregulation of PTEN and the inhibition of cyclooxygenase and prostaglandin E2, can contribute to the suppression of melanoma development [5].

3. Social Behaviour

Melanotan 2 has been known to improve poor social behavior. A study conducted on an autism mouse model shows that MT-II administration had a positive influence on autism-like features, including reduced verbal communication, repetitive behaviors and social isolation [6]. Another study was conducted on female prairie voles, a species known for complex social behavior, particularly in the context of monogamous pair bonding. It found that substances that stimulate oxytocin release, including melanotan 2, can promote social bonding in these species [7].

4. Sexual Health

Literature reveals that melanotan 2 is an effective therapy for men with erectile dysfunction. In research, 9 out of 10 men with psychogenic erectile dysfunction who are unable to achieve erections before sexual activity but can do so while sleeping experienced penile erections after taking MT-II [8]. The effects of this peptide are just not limited to psychogenic erectile dysfunction, it can also improve sexual dysfunction associated with several risk factors [9].

5. Appetite Regulation

Research shows that melanotan 2 regulates appetite and mediates energy expenditure. One study on male mice found that MT-II administration into the brain region involved in rewarding (nucleus accumbens) decreased the amount of food consumed and the motivation to eat [10]. Furthermore, research shows that MT-II mediates energy expenditure and appetite regulation through MC3R and MC4R activation via PMOC signaling. Alpha melanocyte-stimulating hormone signaling might be a potential target for treating obesity [11].


Melanotan II is a synthetic analog of the alpha-melanocyte-stimulating hormone, a naturally occurring peptide. It is known to stimulate melanogenesis and seems to be a promising therapy for obesity and type 2 diabetes. The use of melanotan 2 shots is not approved by the FDA for skin tanning. Melanotan 2 purchase is available for research purposes only. We encourage you to buy melanotan 2 only if you are a qualified researcher.


  1. Banno, R., et al., The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. Peptides, 2004. 25(8): p. 1279-1286.
  2. Heijboer, A.C., et al., Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice. Diabetologia, 2005. 48(8): p. 1621-6.
  3. Lauritzen, E.S., et al., Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial. J Pineal Res, 2022. 73(1): p. E12809.
  4. Goswami, S. and C. Haldar, Melatonin as a possible antidote to UV radiation-induced cutaneous damages and immune-suppression: An overview. Journal of Photochemistry and Photobiology B: Biology, 2015. 153: p. 281-288.
  5. Wu, J.C., et al., Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition. Int J Mol Sci, 2020. 21(2).
  6. Minakova, E., et al., Melanotan-Ii Reverses Autistic Features in a Maternal Immune Activation Mouse Model of Autism. Plos One, 2019..
  7. Young, L., Drugs that stimulate oxytocin release promote social bonding in an animal model relevant to autism. Frontiers in Neuroscience, 2010. 4.
  9. Wessells, H., et al., Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology, 2000. 56(4): p. 641-646.
  10. Eliason, N.L., L. Martin, M.J. Low, and A.L. Sharpe, Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food. Neuropeptides, 2022. 96: p. 102289.
  11. Hsieh, Y.-W., et al., Depletion of Alpha-Melanocyte-Stimulating Hormone Induces Insatiable Appetite and Gains in Energy Reserves and Body Weight in Zebrafish. Biomedicines, 2021. 9(8): p. 941.

Certificate of Analysis (COA)


High Performance Liquid Chromatography (HPLC)


Mass Spectrometry (MS)


What is Melanotan 2

A synthetic peptide called melanotan 2 imitates the body's production of alpha-melanocyte-stimulating hormone (-MSH), a hormone. It is mostly used for its capacity to increase melanin production, the pigment in charge of skin and hair color. Even with little sun exposure, Melanotan 2 can cause tanning of the skin by boosting melanin synthesis. It is frequently sought after as a way to get a natural-looking tan without spending a lot of time in the sun, potentially lowering the risk of sunburn and skin damage from UV radiation. It is crucial to remember that Melanotan 2 usage must be done so responsibly and under a doctor's supervision.

Melanotan 2 Research

Melanotan 2 is a synthetic peptide that has gained attention in scientific research. Here are the key areas of Melanotan 2 research, highlighting its effects and potential applications.

Melanin Stimulation and Tanning:

The capacity of Melanotan 2 to increase the formation of melanin, which results in skin darkening or tanning, is one of the main areas of investigation. By attaching to melanocortin receptors, melanotan 2 stimulates the synthesis of eumelanin, the pigment that gives darker skin and hair color. Researchers have examined Melanotan 2's effectiveness in inducing tanning, minimizing sunburn, and perhaps providing protection against skin damage caused by UV radiation.

Appetite Suppression and Weight Loss:

Research on melanotan 2 has looked into how it might inhibit appetite. Melanotan 2 can lower appetite and food intake, according to studies. Interest in its possible application for managing obesity and weight reduction has been sparked by this substance's ability to decrease hunger. The processes underlying Melanotan 2's effects on appetite control are being studied, as are its potential therapeutic uses in regulating caloric intake.

Sexual Function and Libido:

Melanotan 2's effects on libido and sexual performance have been researched. According to research, Melanotan 2 may have aphrodisiac qualities that could improve sexual performance and desire. Melanotan 2 use has been linked to increased erectile function and sexual desire in both men and women, according to studies. Further investigations are needed to understand the mechanisms underlying these effects and determine its potential applications in the field of sexual medicine.

Skin Protection and Photoprotection:

Research on melanotan 2 has looked into its potential as a photoprotectant. The potential of melanotan 2 to promote melanin synthesis can offer some amount of defense against skin damage brought on by UV radiation. Melanotan 2 treatment has been found in studies to decrease the likelihood of sunburn, boost UV radiation resistance, and maybe provide protection against some skin disorders. The processes underlying Melanotan 2's photoprotective actions are being studied, as well as the substance's potential application in preventing skin damage brought on by UV radiation.

Side Effects and Safety:

Understanding Melanotan 2's safety profile and potential side effects is a key area of research. Possible side effects have been mentioned in studies, including nausea, face flushing, elevated blood pressure, and pigmentation of pre-existing moles. Researchers are exploring ways to mitigate potential adverse effects and enhance the safety profile of Melanotan 2.

Where to Buy Melanotan 2

If you are looking to buy Melanotan 2 online, it is now available for Sale at Pinnacle Peptides at attractive prices. Melanotan 2 for sale is available in a vial of 10MG at our online store. If you are going to buy MT 2, make sure you purchase them from the best in the market. Pinnacle Peptides is renowned for selling MELANOTAN II 10MG in the best form. However mostly they are useful for research purposes only and their human intakes are mostly prohibited.


The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides and reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.

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