What Is AICAR 50MG?
AICAR stands for 5 aminoimidazole-4- carboxamide ribonucleotide. It is a synthetic analog of adenosine monophosphate that regulates the activity of AMP-dependent protein kinase (AMPK). It is under investigation for its effects on insulin resistance, cancer, weight loss and ischemic damage in cardiac myocytes. At Pinnacle Peptides, AICAR for sale is exclusively available for research and experimentation.
Structure Of AICAR 50MG
IUPAC Name: 5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide
Synonyms: MFCD00869751, 37642-57-2
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23 g/mol
CAS number: 37642-57-2
PubChem CID: 266934
Mechanism Of AICAR 50MG
AICAR is taken up by the cells and is phosphorylated to form ZMP (5-aminoimidazole-4-carboxamide ribonucleotide monophosphate). ZMP mimics the function of AMP, a naturally occurring compound that activates AMPK. This, in turn, leads to several downstream effects.
For a better understanding of AICAR, it is important to understand the role of AMPK in the body. It is a cellular energy sensor that is crucial in regulating energy balance. It gets activated in the presence of low energy levels and stimulates catabolic pathways for ATP generation. Further, it also inhibits energy-consuming pathways, such as fatty acid synthesis for the conservation of ATP.
Inflammation plays a significant role in the development of vascular diseases, such as atherosclerosis. One study in the rabbit model of atherosclerosis found that AICAR can inhibit smooth vascular proliferation. Excessive proliferation not only contributes to cardiovascular disease but is one of the major reasons for the failure of cardiac stents over time. Controlling the smooth vascular proliferation through a dependent pathway can improve response to stent and reduce complications without needing medications that increase bleeding risk .
Furthermore, activation of AMPK by AICAR can suppress immune reactions that contribute to the build-up of plaque. Preventing the formation of plaque in the coronary arteries can slow the progression of heart diseases . AICAR can also improve scar formation and reduce adverse remodeling following myocardial infarction through AMPK signalling. This leads to the mobilization of mesenchymal stem cells (MSCs) that ultimately mature into myofibroblasts, resulting in the formation and stabilization of scars. Scar formation is important to replace the damaged necrotic heart tissues that maintain structural integrity and prevent the risk of rupture .
2. Insulin Sensitivity
Inflammation in adipocytes contributes to insulin resistance and poor blood glucose control. Research shows that AICAR has the ability to suppress inflammation in adipocytes that results in improved insulin sensitivity and glucose homeostasis. This was confirmed by a study in diabetic males, revealing that AICAR reduced the hepatic glucose uptake and lowered the blood glucose concentration .
Some studies indicate that the mechanism by which AICAR influences insulin response is similar to that of exercise, i.e., AMPK activation. The activation of AMPK has been shown to increase the expression of GLUT insulin receptors that mediate the uptake of glucose from the blood to the muscles. This results in the effective reduction of blood glucose levels and insulin resistance .
AMPK regulates apoptosis and inhibits cell growth and proliferation . Literature reveals that AICAR exhibits antitumour activity for different kinds of cancer. One study found that AICAR inhibited the growth of cancerous cells in prostate tissues. The effect of AICAR was found to be selective as it didn’t interfere with the growth of non-cancerous cells.
Furthermore, it enhanced the chemosensitivity of docetaxel in prostate cancerous tissues through the regulation of the AMPK/mTOR-dependent pathway . Similarly, it has been shown to inhibit the growth of lung carcinoma and osteosarcoma [8, 9].
Activation of AMPK influences the metabolic state in a healthier way. Research indicates that AICAR, being an activator of AMPK, might have the potential to treat obesity. One study in mice found that AICAR reduced the inflammation in adipocytes, hepatic stenosis and kidney disease. Further, it decreased the production of TNF-alpha and promoted the switching of M1 to M2 macrophage phenotype in tissue explants from obese human subjects. These findings suggest that it might also prevent/attenuate obesity-related complications .
AICAR has also been extensively studied for its effect on sperm motility and energy metabolism. A study conducted on domestic cats found that AICAR can improve the motility and fertilizing ability of cryopreserved sperm . Literature suggests that it might improve sperm motility by enhancing energy metabolism and regulating the activity of energetic enzymes in spermatozoa .
AICAR is a synthetic analog of adenosine monophosphate. It activates AMPK which is responsible for energy balance and homeostasis. AICAR has the potential to treat/ prevent vascular diseases and reduce the adverse remodeling following myocardial infarction. Further, it has been shown to improve insulin sensitivity, inhibit cancer growth and reduce obesity-related complications. It is classified as an investigational drug and hasn’t been approved by the FDA yet. We don’t support its unwarranted use and offer the option to purchase AICAR solely for research. Only buy AICAR if you are an authorized researcher.
- Igata, M., et al., Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression. Circ Res, 2005. 97(8): p. 837-44.
- Rosenfeld, M.E., Macrophage Proliferation in Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 2014. 34(10): p. E21-e22.
- Cieslik, K.A., et al., AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction. J Mol Cell Cardiol, 2013. 63: p. 26-36.
- Boon, H., et al., Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients. Diabetologia, 2008. 51(10): p. 1893-1900.
- Pold, R., et al., Long-Term AICAR Administration and Exercise Prevents Diabetes in ZDF Rats. Diabetes, 2005. 54(4): p. 928-934.
- Zhuge, J., Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR). Cell Biol Toxicol, 2009. 25(3): p. 253-63.
- Su, C.C., et al., AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway. Int J Mol Sci, 2019. 20(7).
- Aftab, F., et al., An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1. British Journal of Cancer, 2023. 128(9): p. 1647-1664.
- Morishita, M., et al., AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway. Int J Oncol, 2017. 50(1): p. 23-30.
- Börgeson, E., et al., AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin. Diabetologia, 2017. 60(4): p. 729-739.
- Thuwanut, P., et al., Activation of adenosine monophosphate-activated protein kinase (AMPK) enhances energy metabolism, motility, and fertilizing ability of cryopreserved spermatozoa in domestic cat model. J Assist Reprod Genet, 2019. 36(7): p. 1401-1412.
- Zhu, Z., et al., 5'-AMP-Activated Protein Kinase Regulates Goat Sperm Functions via Energy Metabolism In Vitro. Cell Physiol Biochem, 2018. 47(6): p. 2420-2431.
What is AICAR?>
Aicar 50MG also known as 5-Aminoimidazole-4-carboxamide ribonucleotide, is a synthetic compound that has gained attention in scientific research. It acts as an activator of AMP-activated protein kinase (AMPK), an enzyme that regulates cellular energy metabolism. AICAR's capacity to activate AMPK imitates the metabolic benefits of exercise by encouraging the synthesis of adenosine triphosphate (ATP), the cellular energy currency. The potential effects of AICAR have been the subject of numerous investigations. In one of these studies, it prevented liver cells from synthesizing cholesterol. According to a human study, it may improve glucose absorption in skeletal muscle cells, including healthy male individuals.
Effects of AICAR
AICAR activates AMPK, improving metabolism, enhancing fat oxidation, and potentially benefiting glucose uptake and insulin sensitivity. Its effects have implications for metabolic disorders and physical performance. Let's explore the effects of AICAR in more detail:
Activation of AMPK:
One of the main effects of AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) is the activation of AMPK. The enzyme AMPK, also known as AMP-activated protein kinase, is essential for controlling cellular energy metabolism. It raises the concentrations of phosphorylated AMPK in cells, which activates AMPK. Once activated, AMPK sets off a series of metabolic reactions that encourage the synthesis and usage of energy. This entails boosting fatty acid oxidation, elevating glucose absorption, and promoting mitochondrial biogenesis. AICAR's activation of AMPK replicates the effects of exercise on metabolism, which makes it a topic of interest for studies into metabolic disorders, ways to enhance physical performance and potential therapeutic uses.
Enhanced Fat Oxidation:
Enhancing fat oxidation is one of AICAR's prominent effects (5-aminoimidazole-4-carboxamide ribonucleotide). The act of dissolving stored lipids and using them as a source of energy is known as fat oxidation. AICAR stimulates AMP-activated protein kinase (AMPK), an enzyme involved in energy control, to enhance fat burning. When AMPK is turned on, it activates pathways that promote fatty acid oxidation and subsequent use in the synthesis of energy. This improved fat oxidation may result in higher fat burning, which may help achieve weight loss or fat loss objectives. It is an exciting substance for research on metabolic diseases, obesity, and weight management because of its capacity to encourage fat oxidation. However, it's important to note that further research is needed to fully understand the extent and long-term effects of AICAR on fat metabolism in humans.
AICAR improves metabolism by making AMPK active. It enhances insulin sensitivity and glucose absorption, improving glycemic management. It also encourages fatty acid oxidation, making it easier to break down stored lipids to generate energy. Additionally, it promotes mitochondrial biogenesis, increasing cellular energy synthesis and metabolic effectiveness. It is a promising substance for study into metabolic diseases, weight management, and future therapeutic uses due to these actions.
AICAR is a fascinating substance for enhancing endurance due to its capacity to activate AMPK. It can promote mitochondrial biogenesis, which leads to higher oxygen use and increased energy generation, improving performance and endurance.
Potential Therapeutic Applications:
Due to AICAR's impact on cellular metabolism and energy management, prospective therapeutic uses have attracted attention. It has been researched for its potential to increase muscle regeneration, enhance athletic performance, and treat metabolic illnesses like diabetes, obesity, and metabolic syndrome.
Uses of AICAR
The basic use of Aicar is in heart-related diseases. Primarily during coronary occlusion, this drug is said to be the preconditioning agent shortly before or during ischemia. It is beneficially useful in the treatment of cardiac cells. It activates AMPK without raising nucleotide levels. This is why it is so useful. It also allows improved blood flow to the coronary cells. Patients with ischemic injury, when treated with Aicar, have been seen to recover quickly and reduce signs of early death. Therefore Aicar 50MG is highly useful for medical purposes.
Where to Buy AICAR Online
This chemical is used for research purposes. It is used for various medicinal purposes or as rug enhancements. This is why it is essential to ensure you buy AICAR from the right place. Pinnacle Peptides provides only the best quality of Aicar for sale so that your tests give the expected results. Pinnacle peptides have thus been trusted by scientists and researchers for delivering the best quality products over time. Currently, it's being sold in vials of 50MG. However, the use of this product is restricted to direct human intake. If you want to purchase it for your research item, you can look at this one or check out other peptides. You will find the highest quality products at the best prices on our website.