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The chemicals/materials for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.

What Is LIQUICIA 30MG / ML | 60ML ?

Tadalafil, sold under the brand name Cialis, belongs to the class, selective phosphodiesterase type 5 inhibitors (PDE5). It is an FDA-approved drug primarily used for the treatment of erectile dysfunction and benign prostatic hyperplasia. It has been shown to increase blood flow to the penis, thus stimulating erection. Furthermore, research shows that it exerts a positive effect on pulmonary arterial hypertension and the cardiovascular system. At Pinnacle Peptides, tadalafil for sale is exclusively available for research and experimentation.

Structure Of LIQUICIA 30MG / ML | 60ML

From Pubchem


IUPAC Name: (2R,8R)-2-(1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
Synonyms: Cialis, Tadanafil
Molecular Formula: C22H19N3O4
Molecular Weight: 389.4 g/mol
CAS number: 171596-29-5
PubChem CID: 110635


Tadalafil was first developed by the collaboration of two companies named ICOS and GlaxoSmithKline in 1991. In 1996, Glaxo discontinued the partnership as drug development was not the company’s core objective. Later, ICOS formed a joint venture named Lilly ICOS with another company Elly Lilly in 1998 to further develop tadalafil. Consequently, the drug was approved by the FDA following the successful completion of clinical trials in 2003. Later, the FDA expanded tadalafil’s approval to treat signs and symptoms of benign prostatic hyperplasia.

Mechanism Of LIQUICIA 30MG / ML | 60ML

Tadalafil has more selectivity to the phosphodiesterase type 5 enzyme as compared to sildenafil. PDE5 is an enzyme present in the smooth muscles of different tissues, including the lungs, prostate, kidney, bladder, cerebellum and urethra.

Normally, sexual stimulation leads to the release of cyclic guanosine monophosphate (cGMP). cGMP acts as a secondary messenger and activates the processes that ultimately lead to the relaxation of smooth muscles in the penile arteries. This, in turn, increases the blood flow to the penis and causes erection.

PDE5 is responsible for catalyzing the breakdown of cGMP. By blocking the action of PDE5, tadalafil prevents the degradation of cGMP and increases its concentration. Enhanced accumulation of cGMP in the penis leads to vasodilatory effects and sustained erection.

Pre-Clinical/Clinical Research

1. Benign Prostatic Hyperplasia

Benign Prostatic hyperplasia (BPH) is characterized by the enlargement of the prostate gland. It is benign (non-cancerous) in nature. It is caused by the excessive proliferation of smooth and epithelial cells in the prostate transition zone. BPH results in obstruction of urinary flow and causes lower urinary tract symptoms, such as dribbling and incomplete urination. Research shows that tadalafil can alleviate discomfort associated with BPH [1,2].

Experts think that the mechanism behind this effect is related to Cialis' ability to boost NO/cGMP activity. This, in turn, decreases the tension in smooth muscle cells and reduces the growth in prostate tissues. Further, it has been shown to stimulate afferent nerves, resulting in enhanced perfusion of blood and decreased inflammation markers [3].

2. Cardioprotective Effect

Research suggests that tadalafil might have the potential to exhibit cardioprotective effects. Tadalafil improves blood flow in coronary arteries through NO/cGMP pathway. Plus, it has also been shown to suppress inflammation, the reason behind various cardiovascular disorders.

One study was conducted to look at the effects of Cialis on a mouse model of diabetes subjected to injury induced by ischemia-reperfusion. Participants were treated with either 1 mg/kg drug or placebo daily for 28 days. The researchers concluded that the treatment lowered the fasting blood glucose and triglyceride levels. It also found that Cialis reduced the infarct size and suppressed the inflammatory cytokines [4].

3. Peripheral Neuropathy

Peripheral Neuropathy is a complication of chronic diabetes. Studies in animal and human models have shown that treatment with PDE5 inhibitors can reduce the symptoms of peripheral neuropathy. Research conducted on animal models found that Cialis improved the conduction velocities in the sciatic nerve. It also found that the drug enhanced the blood flow in the sciatic nerve tissue region and reversed the diabetes-induced reduction in the thickness of myelin and axon diameter [5].

4. Erectile dysfunction

FDA has already approved tadalafil for the treatment of erectile dysfunction. In a double-blind, placebo-controlled trial, ED patients were randomly assigned to two four-week treatment intervals during which they were instructed to engage in sexual intercourse 24 and 36 hours after placebo or drug administration. The findings indicated that tadalafil significantly increased attempts at intercourse, with higher rates observed at both 36 hours (59.2%) and 24 hours (52.9%) after taking tadalafil as compared to the placebo [6].

Furthermore, research suggests that daily use of tadalafil is more effective in enhancing erectile function than on-demand tadalafil [7]. In a long-term efficacy study, tadalafil at doses of 5mg, 10mg, and 20 mg administered daily for up to 18-24 months was generally well tolerated [8]. Furthermore, comparative studies have indicated a potential preference for tadalafil over sildenafil due to its prolonged duration of action [9].

5. Neuroprotection

In addition to regulating cGMP levels, PDE-5 inhibitors have been shown to increase cAMP (cyclic adenosine monophosphate) levels. Both cGMP and cAMP play crucial roles in mediating various brain functions under different physiological and pathological conditions. A study revealed that tadalafil enhances functional recovery in a rat model of embolic stroke. Experts suggested that this improvement might be related to the increased levels of cGMP and enhanced angiogenesis [10].

Tadalafil has been shown to mitigate the effects of spinal cord injury by elevating nitric oxide (NO) and superoxide dismutase (SOD). NO acts as a retrograde transmitter, leading to heightened cGMP production, while SOD neutralizes superoxide radicals, reducing oxidative stress in the body. Through increased NO and SOD production, tadalafil may promote a positive response to injury and alleviate the oxidative stress associated with spinal cord injuries [11].


Tadalafil is a phosphodiesterase type 5 inhibitor. It prevents the degradation of cGMP and improves blood flow to the penis. Furthermore, research shows that it can reduce infarct size following ischemia, improve injury healing and alleviate symptoms of peripheral neuropathy. It is approved by the FDA for the treatment of erectile dysfunction and benign prostatic hyperplasia. At Pinnacle Peptides, we offer tadalafil purchase exclusively for research and educational institutions. Only buy tadalafil if you are a licensed researcher.


  1. McVary, K.T., et al., Tadalafil Relieves Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia. Journal of Urology, 2007. 177(4): p. 1401-1407.
  2. Casabé, A., et al., Efficacy and Safety of the Coadministration of Tadalafil Once Daily with Finasteride for 6 Months in Men with Lower Urinary Tract Symptoms and Prostatic Enlargement Secondary to Benign Prostatic Hyperplasia. Journal of Urology, 2014. 191(3): p. 727-733.
  3. Hatzimouratidis, K., A review of the use of tadalafil in the treatment of benign prostatic hyperplasia in men with and without erectile dysfunction. Ther Adv Urol, 2014. 6(4): p. 135-47.
  4. Varma, A., et al., Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice. PLoS One, 2012. 7(9): p. e45243.
  5. Wang, L., et al., Tadalafil Promotes the Recovery of Peripheral Neuropathy in Type II Diabetic Mice. PLoS One, 2016. 11(7): p. e0159665.
  6. Porst, H., et al., Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial. Urology, 2003. 62(1): p. 121-5; discussion 125-6.
  7. McMahon, C., Comparison of Efficacy, Safety, and Tolerability of On‐Demand Tadalafil and Daily Dosed Tadalafil for the Treatment of Erectile Dysfunction. The Journal of Sexual Medicine, 2005. 2(3): p. 415-427.
  8. Montorsi, F., et al., Long-Term Safety and Tolerability of Tadalafil in the Treatment of Erectile Dysfunction. European Urology, 2004. 45(3): p. 339-345.
  9. Doggrell, S.A., Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction. Expert Opinion on Pharmacotherapy, 2005. 6(1): p. 75-84.
  10. Zhang, L., et al., Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke. Brain Research, 2006. 1118(1): p. 192-198.
  11. Serarslan, Y., et al., Protective effects of tadalafil on experimental spinal cord injury in rats. Journal of Clinical Neuroscience, 2010. 17(3): p. 349-352.

What is Tadalafil?

The drug Tadalafil is frequently referred to by the trade name Cialis. It is a member of the pharmacological class known as phosphodiesterase type 5 (PDE5) inhibitors. Men with erectile dysfunction (ED) are typically treated with tadalafil, although it is also given to treat the symptoms of benign prostatic hyperplasia (BPH). Tadalafil helps to achieve and sustain an erection during sexual stimulation by relaxing the muscles and increasing blood flow to particular regions of the body. It differs from other ED drugs in that it works for a prolonged period of time, lasting up to 36 hours after use.

Tadalafil Research

Due to its efficacy in treating erectile dysfunction (ED) and its potential therapeutic applications in other areas, tadalafil, more widely known by the brand name Cialis, has been the focus of substantial research. The most important tadalafil research findings are summarized in this section.

Erectile Dysfunction:

The effectiveness of tadalafil in treating ED is a key topic of study in this drug. Tadalafil is quite successful at enhancing sexual satisfaction, erectile function, and getting and keeping erections, according to numerous clinical trials. It functions by preventing the activity of the phosphodiesterase type 5 (PDE5) enzyme, which improves erectile function and increases blood flow to the penis.

Benign Prostatic Hyperplasia:

The possibility of using tadalafil to treat the symptoms of benign prostatic hyperplasia (BPH) has also been explored. Tadalafil can increase urine flow and lessen urinary symptoms by relaxing the smooth muscles in the prostate and bladder, according to research. Tadalafil therapy for BPH males has been shown to significantly improve urinary symptoms, quality of life, and overall prostate health.

Pulmonary Hypertension:

Tadalafil has been studied as a potential treatment for pulmonary hypertension, a disorder marked by elevated blood pressure in the arteries that supply the lungs. In individuals with pulmonary hypertension, the ability of tadalafil to relax blood vessels and enhance blood flow has demonstrated promising effects in lowering pulmonary arterial pressure and enhancing exercise capacity.

Cardiovascular Effects:

Tadalafil's effects on the cardiovascular system have also been studied. Tadalafil may improve endothelial function, blood pressure control, and arterial stiffness, according to research. These results suggest that tadalafil may have additional cardiovascular advantages to treating erectile dysfunction.

Safety Profile:

Tadalafil's safety and tolerability have been assessed via research. Tadalafil is generally well tolerated, according to studies, with moderate and temporary side effects being the most frequent. Although serious adverse events are uncommon, persons with particular pre-existing medical disorders or those using particular drugs should proceed with caution. Tadalafil has a good safety record overall, according to research.

Where to Buy Tadalafil

Tadalafil, sometimes referred to as liquid Cialis, is made available by Pinnacle Peptides for research purposes. We are a recognized provider who guarantees the authenticity and high caliber of their research-grade products. Researchers may easily buy Tadalafil online from our website and browse it with convenience. It is significant to remember that Tadalafil is not meant for human consumption and is only to be used in laboratory and scientific study. The appropriate and ethical use of Pinnacle Peptides' products is stressed. To browse our options and make a secure purchase of Tadalafil for their research, researchers can buy this product from the website. With a focus on customer satisfaction and product quality, we provide a reliable source for researchers seeking Tadalafil or liquid Cialis for their scientific investigations. It is essential to adhere to all legal and ethical guidelines for the use of Tadalafil in research settings, and Pinnacle Peptides is committed to supporting responsible research practices.


The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides and reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.

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DISCLAIMER: The products sold on this site are not a drug nor is it intended to treat, diagnose, cure or prevent any disease, nor is it meant for ANY cosmetic purpose. Pinnacle Peptides makes no claims of alleged beneficial properties of any product on this site if injected or ingested in any manner. Our Peptides are exclusively distributed legally within the laws of safe harbor for research peptides and are to be used for that purpose ONLY. If any country’s governing bodies feel we are in violation of their laws regarding peptides, we ask you contact us immediately via [email protected] so we may expeditiously rectify the situation.All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following:Their government regulations regarding the importation, purchase, possession and use of peptides. The health and safety hazards associated with the handling of peptides in a research setting. That peptides are NOT intended to be used as a food additive, drug, vitamin, supplement, cosmetic or any other inappropriate application. Such a sale would be otherwise denied.
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