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For this product you will need: BACTERIOSTATIC WATER For reconstitution.


The chemicals/materials for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested. When you buy tirzepatide it will ship as a freeze dried powder. To research this must reconstituted with bacteriostatic water which is available on on our site.


Tirzepatide is a synthetic analog of gastric inhibitory polypeptide (GIP) with affinity at glucagon-like receptor-1 (GLP-1). It is a linear polypeptide made of 39 amino acids modified with a C20 fatty diacid moiety through a linker at lysine-20. This particular modification extends its durations and allows for weekly subcutaneous dosing. It is approved for type 2 diabetes management and is under active study for its weight loss and cardioprotective effects


From Pubchem


Synonyms: Mounjaro, LY3298176
Molecular Formula: C225H348N48O68
Molecular Weight: 4813 g/mol
CAS number: 2023788-19-2
PubChem CID: 163285897


Eli Lilly and the company first developed tirzepatide and applied for patent in 2016. After the successful completion of clinical trials in type 2 diabetes patients, the company applied for FDA approval in October 2021 with the priority review voucher. In May 2022, tirzepatide was approved for the adjunct treatment of type 2 diabetes under the brand name, Mounjaro. At Pinnacle Peptides, tirzepatide for sale is exclusively available for research


Tirzepatide has a greater affinity to GIP receptors than GLP-1 receptors. GIP is an incretin that is released from the upper small intestine in response to food. It is the main incretin responsible for the insulinotropic effects. GLP-1 is also an incretin that is involved in promoting insulin release, inhibiting glycogen secretion, delaying gastric emptying time and reducing appetite. Tirzepatide’s dual action at GLP-1 and GIP receptors produces a synergistic effect and causes greater hyperglycemic reduction than a selective GLP-1 agonist alone.

Pre-Clinical/Clinical Research

1. Cardioprotective Effects

Research shows that tirzepatide might offer cardioprotective effects. One study found that tirzepatide alleviated cardiac dysfunction induced by lipopolysaccharide and suppressed the inflammatory response in mice. Additionally, it reduced the risk of ventricular arrhythmia and cardiac apoptosis through inhibition of the TLR4/NF-kB/NLRP3 pathway [1].

A follow-up analysis of the SURPASS clinical program found that patients treated with TZP experienced a decrease in systolic blood pressure due to its impact on weight loss [2]. Furthermore, another study discovered that individuals who received TZP had greater reductions in triglyceride levels and LDL-C compared to those given insulin glargine [3]

2. Diabetes

The FDA approved Tirzepatide for type 2 diabetes following a series of successful phase 3 clinical trials conducted in the SURPASS program. These trials provided substantial evidence showcasing tirzepatide's superior effectiveness when compared to a placebo and other medications.

Results from the SURPASS 3 trials have demonstrated that Tirzepatide (TZP) outperforms Insulin Degludec in terms of efficacy. Notably, patients treated with TZP who achieved an HbA1c level of <5.7% over 52 weeks displayed more favorable outcomes in TIT, TTIT, and glycemic variability compared to those who did not reach this target [4].

Furthermore, another study indicates that when combined with insulin glargine, TZP leads to improved glycemic control in patients who were previously unresponsive to insulin glargine [5].

The SURPASS 6 trial has revealed that TZP is more effective in enhancing HbA1c levels and improving the health-related quality of life (HRQoL) in diabetic patients when compared to insulin lispro [6].

3. Weight Loss

The SURPASS 1-5 trials, which investigated the anti-diabetic effects of tirzepatide, have also demonstrated a significant impact of TZP on weight loss. A meta-analysis of these trials reveals that 43% of patients who received TZP lost more than 15 kilograms of body weight [7].

In the SURAMOUNT trial 1, researchers assessed the safety and effectiveness of tirzepatide in obese individuals. They enrolled 2539 participants in the study and randomly assigned them to receive subcutaneous TZP (at doses of 5mg, 10mg, or 15mg) or a placebo for 72 weeks. The findings indicated that the percentage of participants achieving more than a 5% reduction in weight was 85% for 5mg, 89% for 10mg, and 91% for 15mg. These stats clearly indicate TZP’s superior efficacy compared to the placebo [8].

Furthermore, SURAMOUNT trial 2 found that 79-83% of individuals treated with TZP experienced more than 5% weight loss, in contrast to the control group where only 32% achieved this level of weight reduction [9].


Tirzepatide is an FDA-approved drug for the adjunct treatment of type 2 diabetes. Further clinical trials under SURAMOUNT program are underway to establish the safety and efficacy of tirzepatide for weight loss. Pinnacle peptides offer the option to purchase tirzepatide for research purposes only, not for human consumption. We encourage you to buy tirzepatide from us only if you are an authorized researcher.


  1. Kellerer, Liu, Q., et al., Tirzepatide attenuates lipopolysaccharide-induced left ventricular remodeling and dysfunction by inhibiting the TLR4/NF-kB/NLRP3 pathway. International Immunopharmacology, 2023. 120: p. 110311.
  2. Lingvay, I., et al., Systolic blood pressure reduction with tirzepatide in patients with type 2 diabetes: insights from SURPASS clinical program. Cardiovascular Diabetology, 2023. 22(1): p. 66.
  3. Kahn, S., et al., IDF2022-0918 Tirzepatide Reduces Serum Triglyceride Irrespective of Fibrate Use in People With T2D at High CV Risk (SURPASS-4). Diabetes Research and Clinical Practice, 2023.
  4. BERGENSTAL, R.M., et al., 764-P: Time in Range and Time in Tight Range in Tirzepatide-Treated Patients Achieving Normoglycemia in the SURPASS-3 CGM Substudy. Diabetes, 2023. 72(Supplement_1).
  5. Dahl, D., et al., Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial. Jama, 2022. 327(6): p. 534-545.
  6. BOYE, K., et al., 753-P: Tirzepatide Improves HRQoL Compared with Insulin Lispro in Poorly Controlled Basal Insulin–Treated Adults with Long-Standing T2D (SURPASS-6). Diabetes, 2023. 72(Supplement_1).
  7. Malecki, M., et al., IDF2022-0369 Predictors of Achieving Weight Loss ≥15% With Tirzepatide in People With Type 2 Diabetes From SURPASS 1-4. Diabetes Research and Clinical Practice, 2023.
  8. Jastreboff, A.M., et al., Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 2022. 387(3): p. 205-216.
  9. Garvey, W.T., et al., Tirzepatide Once Weekly for the Treatment of Obesity in People With Type 2 Diabetes (SURMOUNT-2): A Double-Blind, Randomised, Multicentre, Placebo-Controlled, Phase 3 Trial. The Lancet, 2023.

Certificate of Analysis (COA)


High Performance Liquid Chromatography (HPLC)


Mass Spectrometry (MS)


What is Tirzepatide?

Tirzepatide is a novel medication that falls under GLP-1 anand GIP receptor agonists. It is a synthetic peptide designed to mimic the activity of the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) hormones. By targeting both GLP-1 and GIP receptors, Tirzepatide aims to regulate blood sugar levels, stimulate insulin secretion, and promote weight loss. As a cutting-edge peptide-based medication, Tirzepatide offers a promising avenue for scientific exploration. With its dual action on the GLP-1 and GIP receptors, Tirzepatide has gained attention for its potential in managing diabetes and promoting weight loss.

Tirzepatide Research

To treat type 2 diabetes mellitus, Tirzepatide is an experimental dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) compound. The study on Tirzepatide is reviewed here, emphasizing its mechanisms of action, clinical efficacy, and related investigations.

Mechanisms of Action

Tirzepatide combines the effects of GIP and GLP-1, two incretin hormones that exist naturally and are involved in the control and metabolism of glucose. Tirzepatide enhances insulin secretion, inhibits glucagon production, slows stomach emptying, and encourages sensations of fullness by activating the GIP and GLP-1 receptors. Together, these pathways support better glycemic management and weight loss.

Clincal Effectiveness

Glycemic Control:

Tirzepatide dramatically lowers glycated hemoglobin (HbA1c) levels in clinical trials, demonstrating improved glucose management. It is more effective than other anti-diabetic drugs, such as sodium-glucose cotransporter-2 (SGLT-2) inhibitors and GLP-1 RAs.

Tirzepatide for Weight Loss:

Tirzepatide has demonstrated the ability to cause weight loss in people with type 2 diabetes. Clinical investigations have shown that Tirzepatide treatment significantly lowers body weight, body mass index (BMI), and waist circumference compared to placebo or other anti-diabetic drugs.

Cardiovascular Benefits:

The effects of Tirzepatide on cardiovascular outcomes in people with type 2 diabetes have been studied. Studies have shown a decrease in serious adverse cardiovascular events, such as fatal heart attacks, nonfatal myocardial infarctions, and stroke, pointing to possible advantages for the heart.

Clinical Studies

SURPASS Program:

Tirzepatide's safety and effectiveness in people with type 2 diabetes have been studied in the SURPASS clinical trial program. In these studies, Tirzepatide outperformed other anti-diabetic medications regarding glycemic control and weight loss, demonstrating the drug's promise as a cutting-edge therapy alternative.

SELECT Program:

The cardiovascular effects of Tirzepatide usage have been specifically evaluated in the SELECT studies. These studies indicate this peptide may have potential cardiovascular benefits by demonstrating a decrease in serious adverse cardiovascular events.

Where to Buy Tirzepatide

If you want to purchase Tirzepatide for research purposes, you invest in a versatile tool to investigate its mechanisms and therapeutic applications. Unlock the secrets of Tirzepatide for weight loss and other areas of interest by incorporating it into your research studies. Explore its impact on glucose regulation, appetite control, and metabolic pathways. With its once-weekly dosing and proven efficacy in clinical trials, Tirzepatide offers convenience and promising results. You can conveniently buy Tirzepatide online from Pinnacle Peptides to fuel your research endeavors. Take the next step in advancing your scientific studies and unravel the potential of Tirzepatide 5mg. Embrace the opportunity to contribute to scientific knowledge and improve metabolic health. At present, Tirzepatide for sale here is available in vials of 5 MG at the online store of Pinnacle Peptides.


The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges the risks of consuming or distributing these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals, or other inappropriate applications. Listing a material on this site does not constitute a license to its use in infringement of any patent. The products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their review and study, they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products—the health and safety hazards associated with handling the products they purchase. An adequate warning of any products' health and safety hazards is necessary. Pinnacle Peptides reserves the right to limit and deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.

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DISCLAIMER: The products sold on this site are not a drug nor is it intended to treat, diagnose, cure or prevent any disease, nor is it meant for ANY cosmetic purpose. Pinnacle Peptides makes no claims of alleged beneficial properties of any product on this site if injected or ingested in any manner. Our Peptides are exclusively distributed legally within the laws of safe harbor for research peptides and are to be used for that purpose ONLY. If any country’s governing bodies feel we are in violation of their laws regarding peptides, we ask you contact us immediately via [email protected] so we may expeditiously rectify the situation.All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following:Their government regulations regarding the importation, purchase, possession and use of peptides. The health and safety hazards associated with the handling of peptides in a research setting. That peptides are NOT intended to be used as a food additive, drug, vitamin, supplement, cosmetic or any other inappropriate application. Such a sale would be otherwise denied.
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