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The chemicals/materials for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.

What Is YOHIMBINE HC 10 MG / ML | 60ML?

Yohimbine, also known as quebrachine, is an inhibitor of the α2-adrenergic receptor. It is alkaloid in nature and is derived from Pausinystalia Yohimbe and Rauwolfia serpentina. Its history dates back to 1934 when it was discovered by an American botanist named R. Raymond Hamet from several herb species. It has been used as an aphrodisiac in folk medicine. Furthermore, research shows that it exhibits a cardioprotective effect, promotes weight loss and might prove helpful in the treatment of cancer. At Pinnacle Peptides, yohimbine for sale is exclusively available for research and experimentation.

Structure Of YOHIMBINE HC 10 MG / ML | 60ML

From Pubchem


IUPAC Name: (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
Synonyms: Yohimbin, Quebrachin, Quebrachine
Molecular Formula: C21H26N2O3
Molecular Weight: 354.4 g/mol
CAS number: 146-48-5
PubChem CID: 8969

Mechanism Of YOHIMBINE HC 10 MG / ML | 60ML

Yohimbine’s exact mechanism of action is unknown. However, research indicates that it acts as an antagonist at the α2-adrenergic receptor located on the presynaptic nerves. It selectively binds to α2 receptors and has shown low affinity towards α1 receptors. Blockage of these receptors enhances sympathetic nerve stimulation and norepinephrine levels in the blood.

Furthermore, it stimulates the release of NO which promotes vasodilation and increases blood flow to the penis, resulting in erection. Studies show that yohimbine also exhibits some activity at dopaminergic and serotonin receptors.

Pre-Clinical/Clinical Research

1. Blood Clotting

α2-adrenergic receptors play an important role in the regulation of blood clotting. Since yohimbine has been shown to block these receptors, it might help prevent the onset of stroke and myocardial infarction in patients with low INR values. One study on healthy individuals found that the minimum effective dose of yohimbine to inhibit platelet aggregation was 8 mg. This particular effect lasted 12 hours when a 12mg dose was administered [1]. Furthermore, research shows that it can prevent orthostatic-induced platelet aggregation, thus it might reduce the risk of thrombotic vascular events in patients with atherosclerosis [2].

2. Cancer

Research shows that epinephrine and norepinephrine stimulate the physiological processes that promote cell proliferation in cancer cells. Furthermore, G protein-coupled receptors, including α2-adrenergic receptors, are associated with various forms of cancer.

Yohimbine exhibits antagonist action at these receptors and might slow down the progression of cancer. One study found that Yohimbine’s derivative, Y7, can block the vasopressin and oxytocin receptors that are associated with prostate and lung cancer [3, 4]. Moreover, it has been shown that administration of yohimbine lowers the levels of PSA and steroid 5-α reductase, thus indicating that it might be effective for the treatment of benign prostatic hyperplasia [5].

3. Sexual dysfunction

A dose escalation study was designed to demonstrate the safety and efficacy of yohimbine in men with hypertension. It found that yohimbine resulted in a 100% erectile response among responders, with a more pronounced effect observed in non-smokers and individuals with less severe erectile dysfunction [6]. In a rat study, it was proposed that yohimbine exerts its effects on the spinal level by acting on both α1 and α2 adrenergic receptors [7].

4. Myocardial Dysfunction

Research indicates that inhibition of α2 adrenergic receptors can mitigate septic cardiomyopathy by suppressing endothelial activation [8]. Furthermore, yohimbine has been shown to reverse the LPS-induced reduction in left ventricular ejection fraction, stroke volume, and cardiac output in rats [9]. Similarly, another study suggests that pretreatment with yohimbine, in combination with berberine, may prevent LPS-induced myocardial infarction. This protective effect is attributed to the inhibition of myocardial apoptosis and the reduction of nitric oxide production [10].

5. Weight loss

One study was designed to investigate the effect of yohimbine on weight loss in rat model of obesity. The results found that it reduced appetite, improved lipid profiles and decreased adipose tissue fat [11]. The weight loss effects of yohimbine were further confirmed by a study in athletes where yohimbine administration resulted in a significant reduction in fat mass as compared to the control [12].


Yohimbine is an alkaloid derived from the herb species. It is an antagonist of the α2 adrenergic receptor located at the presynaptic nerve. It has been shown to improve sexual function and reduce the risk of cancer. Animal studies indicate that it reduces the consequences associated with myocardial infarction. Furthermore, it has been shown to promote weight loss. It has not been approved by the FDA yet. We don’t support its unwarranted use and offer yohimbine purchase exclusively for research and experimentation. Only buy Yohimbine if you are a licensed researcher.


  1. Berlin, I., et al., The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects. Clin Pharmacol Ther, 1991. 49(4): p. 362-9.
  2. Andrews, N.P., D.S. Goldstein, and A.A. Quyyumi, Effect of systemic alpha-2 adrenergic blockade on the morning increase in platelet aggregation in normal subjects. Am J Cardiol, 1999. 84(3): p. 316-20.
  3. Zhong, M., et al., Oxytocin induces the migration of prostate cancer cells: involvement of the Gi-coupled signaling pathway. Mol Cancer Res, 2010. 8(8): p. 1164-72.
  4. Paciaroni, N.G., et al., Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets. Bioorg Med Chem, 2020. 28(14): p. 115546.
  5. Zhao, Y., et al., Yohimbine hydrochloride inhibits benign prostatic hyperplasia by downregulating steroid 5α-reductase type 2. Eur J Pharmacol, 2021. 908: p. 174334.
  6. Guay, A.T., et al., Yohimbine treatment of organic erectile dysfunction in a dose-escalation trial. Int J Impot Res, 2002. 14(1): p. 25-31.
  7. Carro-Juáreza, M. and G. Rodríguez-Manzo, Yohimbine reverses the exhaustion of the coital reflex in spinal male rats. Behav Brain Res, 2003. 141(1): p. 43-50.
  8. Yu, X., et al., α(2A)-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation. Sci Rep, 2018. 8(1): p. 5478.
  9. Wang, Y., et al., Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of the presynaptic α2A-adrenergic receptor. PLoS One, 2013. 8(5): p. e63622.
  10. Wang, Y.Y., et al., Pretreatment with berberine and yohimbine protects against LPS-induced myocardial dysfunction via inhibition of cardiac I-[kappa]B[alpha] phosphorylation and apoptosis in mice. Shock, 2011. 35(3): p. 322-8.
  11. Dudek, M., et al., A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity. PLoS One, 2015. 10(10): p. e0141327.
  12. Ostojic, S.M., Yohimbine: the effects on body composition and exercise performance in soccer players. Res Sports Med, 2006. 14(4): p. 289-99.

What is Yohimbine?

Yohimbine is a naturally occurring substance obtained from the bark of the African yohimbe tree (Pausinystalia yohimbe). It is well known for its possible impact on sexual health, fat metabolism, and vitality. Yohimbine functions as an alpha-2 adrenergic receptor antagonist, which might raise adrenaline levels and encourage lipolysis, thereby assisting in weight loss and enhancing physical performance. In addition, it's frequently used as a herbal supplement to enhance sexual health and treat erectile dysfunction symptoms. Yohimbine may have negative effects and interact with some drugs, therefore it is crucial to use it carefully and under medical supervision.

Yohimbine Research

Yohimbine, a naturally occurring substance derived from the bark of the yohimbe tree, has drawn considerable study interest because of its potential impact on a number of aspects of health and wellness. This article is a summary of the yohimbine research, emphasizing its uses in energy metabolism, weight management, sexual health, and other areas of study.

Energy Metabolism and Weight Management:

Yohimbine research has a significant field dedicated to studying how it affects weight management and energy metabolism. Studies have looked into how its function as an alpha-2 adrenergic receptor antagonist can promote lipolysis, the breakdown of accumulated fat. The processes by which yohimbine may boost energy expenditure and maybe aid weight loss attempts are being studied. To clarify its role in achieving the best body composition and controlling obesity, clinical trials investigate its efficacy as a supplement when combined with physical activity and calorie restriction.

Sexual Health and Erectile Dysfunction:

Yohimbine has been researched for its possible advantages in treating erectile dysfunction and other sexual health issues. Yohimbine may increase erectile function and sexual excitement by increasing blood flow to the vaginal area, according to research. Studies investigate its effectiveness as a stand-alone therapy or in conjunction with additional therapies, such as phosphodiesterase type 5 (PDE5) inhibitors or counseling. The research advances knowledge of yohimbine's mechanisms of action and its potential as an additional treatment for erectile dysfunction.

Adverse Effects and Safety Considerations:

Research on yohimbine also looks at possible side effects and safety issues. Studies look at the best dosage, possible drug interactions, and adverse effects of yohimbine use. These could consist of heart problems, anxiety, gastrointestinal problems, and high blood pressure. Yohimbine use guidelines are being developed, emphasizing the need for adequate dosage and care in specific populations, such as individuals with cardiovascular disease or mental health issues.

Other Areas of Investigation:

Yohimbine's potential uses go beyond energy metabolism and sexual health, according to other research areas. Its effects on mood and anxiety disorders, as well as its impact on memory and cognitive function, have all been the subject of research. Preclinical research have looked into its conceivable anti-inflammatory and anti-diabetic effects. Yohimbine's influence on exercise performance has also been studied, with research looking at its effects on strength, endurance, and tiredness.

Where to Buy Yohimbine

If you are looking to buy Yohimbine online for research purposes, Look no further than Pinnacle Peptides. Researches call for the use of authentic products like Yohimbine in their lead experiments. While you might be going through a dozen of websites for confirming the authentic supply of this formulation, at Pinnacle Peptides would be waiting for an opportunity for proving the authenticity of the products. At Pinnacle Peptides you can be sure of being served high quality products for lesser rates. We provide high-quality Yohimbine for sale that is ideal for scientific research. To assure purity and effectiveness, our products go through extensive testing. Pinnacle Peptides knows the value of accurate and trustworthy findings in study, which is why we offer top-notch Yohimbine to researchers. We got you covered whether you're researching energy metabolism, controlling your weight, sexual wellness, or other topics of interest. Purchase Yohimbine from Pinnacle Peptides and rely on our knowledge to help your research efforts. Yohimbine is made available in an attractive package of 10 mg vial at our online store. Derived originally from yohimbe tree bark, this product is especially imported for sale from western African countries. The purchase of this product can be clubbed with the other ones for gaining access to the discounted price list that this website has to offer. Check out the wide range of research peptides that Pinnacle Peptides has to offer. Special offers are always on for the researchers and scientists who opt for the purchase of research products through the online store on a regular basis.


The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.

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