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What Is FRAGMENT 176-191- 5MG?
Fragment 176-191, also known as AOD9604, is a synthetic peptide derived from fragment 176-191 at the C-terminus of human growth hormone. It is sometimes referred to as a lipolytic fragment of growth hormone as this part is associated with fat metabolism. Research shows that it lowers blood glucose levels without altering insulin sensitivity. It also stimulates lipolysis and inhibits lipogenesis.
The research involving frag 176-191 is limited. Studies show that it has a similar mechanism of action as AOD9604. AOD9604 is another fragment (177-191) of the human growth hormone that binds to GH receptors and produces a GH-like effect on the metabolism of cartilage without stimulating the proliferation of cells. It is available as a research chemical and is not approved by FDA. At Pinnacle Peptides, Fragment 176-191 for sale is exclusively available for qualified researchers.
Structure Of FRAGMENT 176-191- 5MG
Synonyms: 66004-57-7, Hgh (176-191), DTXSID10216216
Molecular Formula: C78H123N23O22S2
Molecular Weight: 1799.1 g/mol
CAS number: 66004-57-7
PubChem CID: 16131230
1. Frag 176-191 and Fat loss
Studies on animal models show that lipolytic fragments of the human growth hormone can induce fat-burning and weight loss. One study in obese Zucker rats was conducted to assess its lipolytic effect. The subjects were given AOD9604 of 500 microg/kg body weight or placebo for 19 days. The results found that the treatment group observed a 50% reduction in weight gain as compared to the control group. The data suggests that the lipolytic fragment of growth hormone might have the potential to be developed into a safe oral dose for obesity .
In another study, chronic administration of AOD9604 for 14 days reduced body weight and body fat in obese mice. Further, this synthetic fragment increased the repressed expression of beta-3 adrenergic receptors in obese mice to levels comparable to those found in lean mice. The activation of these receptors stimulates fat burning in adipose tissue and enhances thermogenesis in skeletal muscles. Mice with no gene for beta-3 adrenergic receptors didn’t experience changes in body composition or an increase in lipolysis .
2. Frag 176-191 and Diabetes
Research shows that the lipolytic fragment of human growth hormone might benefit diabetes. A study was conducted to examine the effect of fragments of growth hormone, involving frag 176-191, on glucose levels. The researchers found that out of all tested fragments, 176-191 was most effective for lowering blood sugar levels. This effect was secondary to an increase in the levels of plasma insulin and reduced insulin sensitivity .
3. Frag 176-191 and Cartilage Regeneration
Research indicates that the C- terminus peptide of human growth hormone might promote cartilage regeneration. One study investigated the effect of intra-articular injections of AOD906 with or without hyaluronic acid in a knee osteoarthritis rabbit model. Subjects were given either saline, hyaluronic acid, AOD9604 or AOD9604 with hyaluronic acid. The results indicated that AOD9604 enhanced cartilage regeneration and its combination with hyaluronic acid had an even more pronounced effect .
Frag 176-191 is a modified form of the human growth hormone fragment 176-191 at the C-terminus. Research shows that it might be able to induce fat and weight loss in obese persons, promote cartilage regeneration and benefit diabetic people. The current research on this topic is quite limited; however, there is significant potential for further exploration and investigation. It is a research molecule, which means you can only purchase fragment 176-191 for research. If you are wondering where to buy fragment 176-191, shop from Pinnacle Peptides to elevate your research.
- Ng, F.M., et al., Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res, 2000. 53(6): p. 274-8.
- Heffernan, M., et al., The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology, 2001. 142(12): p. 5182-9.
- Ng, F.M. and J. Bornstein, Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol, 1978. 234(5): p. E521-6.
- Kwon, D.R. and G.Y. Park, Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci, 2015. 45(4): p. 426-32.
Certificate of Analysis (COA)
High Performance Liquid Chromatography (HPLC)
What is Fragment 176-191?
The synthetic peptide fragment 176-191, commonly known as AOD-9604, is produced from the human growth hormone (HGH). The HGH chain's amino acids 176 to 191 make up this protein. Attention has been drawn to fragment 176-191 because of its possible anti-obesity and fat-reduction properties. It is thought to function by encouraging lipolysis, the breakdown of fats that have been accumulated, and preventing lipogenesis, the process of fat synthesis. According to research, Fragment 176-191 may specifically target receptors involved in the metabolism of fat, causing localized fat loss. To completely comprehend its methods of action and maximize its application for fat loss, however, more research is required.
Fragment 176-191 Research
Fragment 176-191, also known as AOD-9604, has been the subject of scientific research due to its potential fat-reducing and anti-obesity properties. Here is an overview of the research conducted on Fragment 176-191:
Lipolysis and Fat Reduction:
Studies have concentrated on Fragment 176-191's capacity to encourage lipolysis, or the breakdown of fat reserves. According to research, Fragment 176-191 selectively targets fat cells, causing them to leak fatty acids and preventing them from dividing. This peptide may promote the use of fats as an energy source, which could reduce body fat and improve body composition.
It has being researched whether fragment 176-191 has anti-obesity properties. Studies on humans and animals have produced encouraging findings regarding the reduction of body weight, fat mass, and waist circumference. According to some theories, Fragment 176-191 may directly affect adipocytes and adipose tissue, causing them to reduce their ability to retain fat.
Studies have looked into the metabolic effects of fragments 176–191. In both animal models and human individuals, it has been shown to improve lipid profiles, glucose tolerance, and insulin sensitivity. Fragment 176-191 may improve glucose management and insulin action, which could improve metabolic health.
Safety and Side Effects:
The safety profile of Fragment 176–191 has also been the subject of research. According to studies, it generally has few adverse effects and is well tolerated. To guarantee its safety when used for lengthy periods of time, additional long-term safety studies and monitoring are required.
Optimization and Dosage:
Fragment 176–191 optimization and dosage: Studies have looked into the best dosage schedules and delivery methods. Studies have investigated various delivery strategies, such as subcutaneous injections, to find the most productive and successful ones. To improve dosage recommendations and assess the long-term consequences of various dosing approaches, more investigation is required.
Where to Buy Fragment 176–191
Best quality Fragment 176-191 for sale is available at our online store. Scientists and researchers who want to purchase Fragment 176-191 online can order their requirements at our website. Pinnacle Peptides has been trusted for several years by many scientists. The shipments are delivered to both national and international customers. We are your most trusted online source if you are willing to buy this peptide or other important peptides. This peptide is available in vials of 5MG. However, it is available for purchase only for research purposes.
The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.