98 % of 100
In stock
  • Buy 3 for $62.99 each and save 10%
  • Buy 6 for $57.99 each and save 17%
  • Buy 10 for $50.99 each and save 27%
699.9 Reward Points will be used to purchase this product

Buy this product and Earn 20.00 Pinnacle Points click here to login

The chemicals/materials for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.

What Is LIQUIVIA 25MG / ML | 60ML?

Sildenafil, sold under the brand name Viagra, is an inhibitor of phosphodiesterase type 5 enzyme (PDE5). It is an FDA-approved drug primarily indicated for the treatment of erectile dysfunction and pulmonary arterial hypertension. It is often prescribed off-label for female infertility and the Raynaud phenomenon. Furthermore, it has been shown to improve alopecia. Currently, it is being studied for its effect on urinary incontinence, skin reactions, and other conditions. At Pinnacle Peptides, sildenafil for sale is exclusively available for research and experimentation.

Structure Of LIQUIVIA 25MG / ML | 60ML

From Pubchem


IUPAC Name: 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
Synonyms: 139755-83-2, Aphrodil, Vizarsin, Patrex
Molecular Formula: C22H30N6O4S
Molecular Weight: 474.6 g/mol
CAS number: 139755-83-2
PubChem CID: 135398744


Sildenafil was first developed by a group of scientists at Pfizer. They initially studied it for the management of angina and pulmonary arterial hypertension. Clinical trials on the drug didn’t show any significant effect on angina, but the researchers found that it can induce erection. Based on the discovery, Pfizer decided to market it for the treatment of erectile dysfunction. In 1998, it was approved by the FDA for erectile dysfunction following the successful completion of clinical trials.

Mechanism Of LIQUIVIA 25MG / ML | 60ML

Phosphodiesterase type 5 enzyme is responsible for catalyzing the breakdown of cGMP. Sildenafil mimics the action of cGMP and competitively binds to the active site of PDE5. This, in turn, prevents the PDE5 from metabolizing cGMP, resulting in the raised intracellular concentration of cGMP. The accumulation of cGMP in the cells increases the cGMP-dependent phosphatase kinase activity, leading to the phosphorylation of different proteins in the smooth muscles. It results in increased potassium efflux, and decreased intracellular calcium levels, thus causing relaxation of smooth muscles.

Relaxation of smooth muscle cells in the penis gland increases blood flow to the organ, thus causing erection. Similarly, vasodilation in pulmonary arterial hypertension leads to decreased resistance to blood flow. This, in turn, reduces the mean arterial pressure.

Pre-Clinical/Clinical Research

1. Raynaud Phenomenon

Raynaud Phenomenon is a medical condition characterized by the vasospasm in the toes and fingers in response to the cold or stress. It limits the blood flow to the affected areas, causing paleness, numbing and tingling. As sildenafil promotes the relaxation of smooth muscles in blood vessels, it might improve this condition. One study found that it effectively reduced the frequency of attacks in Raynaud phenomenon secondary to systemic sclerosis [1]. Furthermore, another study concludes that sildenafil is well-tolerated and effective for the treatment of RP [2].

2. Erectile Dysfunction

One study was designed to investigate the effect of sildenafil on sexual dysfunction associated with the use of antidepressants. Forty-nine female patients who were taking selective serotonin reuptake inhibitors were enrolled in the study. They were randomized to receive a placebo or sildenafil before engaging in sexual activity. The results found that the treatment significantly reduces the sexual side effects of antidepressants [3]. Similarly, another study found that sildenafil also improves erectile function and reduces sexual dysfunction associated with the use of SRIs in men [4].

Furthermore, research indicates that sildenafil shows promising results in the treatment of erectile dysfunction induced by spinal cord injury. However, the sacral or thoracolumbar region needs to be intact for successful results [5].

3. Alopecia

Sildenafil has demonstrated significant efficacy in the treatment of alopecia. One study revealed that it increased the vertical and terminal hair count in men with androgenic alopecia [6]. Furthermore, another study compared the effect of 5% minoxidil and 1% sildenafil on female pattern hair loss. Researchers observed that 1% sildenafil increased terminal and vellus hair count in the vertex, temporal, and frontal sides [7].

4. Exercise Capacity

Lack of oxygen delivery to muscles due to insufficient blood flow reduces exercise tolerance in patients with pulmonary hypertension. Since sildenafil induces vasodilation, it might improve exercise capacity in such patients. One study from SUPER trials found that sildenafil significantly improved peak VO2, peak O2 pulse, and PETCO2, indicating increased exercise tolerance [8].

5. Pulmonary Arterial Hypertension

Sildenafil has been already approved by the FDA for the treatment of WHO group 1 pulmonary arterial hypertension (PAH). Research shows that the combination of sildenafil and milrinone is effective for the PAH in neonates as compared to the sildenafil alone. Furthermore, it is recommended in resource-limited settings [9].

Patients with long-standing mitral valve disease often suffer from pulmonary arterial hypertension. Elevated arterial pressure in lungs during the mitral valve surgery has been shown to cause right ventricular failure. Sildenafil might ensure a safe and successful procedure. One study revealed that sildenafil administration before a surgical procedure can improve pulmonary arterial pressure before and after the surgery [10].


Sildenafil is a phosphodiesterase type 5 inhibitor used for the treatment of erectile dysfunction and PAH. It competitively binds to PDE5 and facilitates the relaxation of smooth muscles. It improves androgenic alopecia and exercise capacity in patients with PAH. At Pinnacle Peptides, we offer the option to purchase Viagra exclusively for research and educational institutions. This product is not intended for human consumption, only buy Viagra if you are a licensed researcher.


  1. Herrick, A.L., et al., Modified-release sildenafil reduces Raynaud's phenomenon attack frequency in limited cutaneous systemic sclerosis. Arthritis & Rheumatism, 2011. 63(3): p. 775-782
  2. Fries, R., K. Shariat, H.v. Wilmowsky, and M. Böhm, Sildenafil in the Treatment of Raynaud’s Phenomenon Resistant to Vasodilatory Therapy. Circulation, 2005. 112(19): p. 2980-2985.
  3. Nurnberg, H.G., et al., Sildenafil Treatment of Women With Antidepressant-Associated Sexual Dysfunction: A Randomized Controlled Trial. JAMA, 2008. 300(4): p. 395-404.
  4. Nurnberg, H.G., et al., Treatment of Antidepressant-Associated Sexual Dysfunction With Sildenafil: A Randomized Controlled Trial. JAMA, 2003. 289(1): p. 56-64.
  5. Schmid, D.M., B. Schurch, and D. Hauri, Sildenafil in the Treatment of Sexual Dysfunction in Spinal Cord–Injured Male Patients. European Urology, 2000. 38(2): p. 184-193.
  6. Al-Shabkhon, A.A., A.A. Halim Emam, and A. Abd Elfattah Afify, Comparative study between the efficacy of topical sildenafil and topical minoxidil in the treatment of male androgenic alopecia. QJM: An International Journal of Medicine, 2021. 114(Supplement_1).
  7. Mostafa, H.A., H.A.K. Mohammed, and I. Fouda, Comparative Study Between the Efficacy and Safety of Topical Sildenafil Citrate Solution and Topical Minoxidil 5%in the Treatment of Female Pattern Hair Loss. 2022.
  8. Oudiz, R.J., et al., Effect of sildenafil on ventilatory efficiency and exercise tolerance in pulmonary hypertension. European Journal of Heart Failure, 2007. 9(9): p. 917-921.
  9. El-Ghandour, M., B. Hammad, M. Ghanem, and M.A.M. Antonios, Efficacy of Milrinone Plus Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension in Resource-Limited Settings: Results of a Randomized, Double-Blind Trial. Pediatric Drugs, 2020. 22(6): p. 685-693.
  10. Villanueva, D.L.E., R.D. Agustin, and E.J. Llanes, Pre-Operative Sildenafil for Patients With Pulmonary Hypertension Undergoing Mitral Valve Surgery: A Systematic Review and Meta-Analysis. Cardiol Res, 2019. 10(6): p. 369-377.

What is Sildenafil?

Sildenafil is the generic version of Viagra, containing the same active ingredient as Viagra and Viagra Connect. The medicine sildenafil is a member of the group of medications known as phosphodiesterase type 5 (PDE5) inhibitors. Men with erectile dysfunction (ED), a disorder marked by the inability to obtain or sustain an erection appropriate for sexual engagement, are the target audience for this medication. Sildenafil increases blood flow by relaxing the blood vessels in the penis, which promotes an erection. A disorder that affects the blood arteries in the lungs, pulmonary arterial hypertension (PAH), is another ailment for which it is also given. In those with PAH, sildenafil aids in enhancing exercise capacity and easing symptoms.

Sildenafil Research

Numerous studies have been conducted on sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, across a number of medical specialties. Beyond its well-known use in the treatment of erectile dysfunction (ED), studies have looked into its efficacy, safety, and future applications.

Erectile Dysfunction Treatment:

The use of sildenafil in the management of erectile dysfunction is an important field of research. Its effectiveness in enhancing erectile function, which increases the capacity to attain and maintain erections appropriate for sexual engagement, has been tested in clinical trials. No matter the underlying etiology of the majority of men with ED, including those with organic, psychogenic, or mixed etiologies, research has shown that sildenafil is efficacious.

Cardiovascular Effects:

Sildenafil study has also examined its effects on the cardiovascular system, notably in people with cardiovascular disease. Studies have looked into the security and potential advantages of sildenafil in illnesses like hypertension, heart failure, and coronary artery disease. According to studies, people with specific cardiovascular diseases who use sildenafil had improved exercise capacity, hemodynamic indicators, and quality of life. However, it needs to be carefully assessed and monitored when used in people with severe cardiovascular disease.

Pulmonary Arterial Hypertension:

The use of sildenafil in the management of pulmonary arterial hypertension (PAH) is another crucial field of sildenafil research. According to studies, sildenafil can help PAH patients exercise more effectively, delay the disease's progression, and lessen their symptoms. Research has also looked into the possibility of using Sildenafil in combination with other drugs designed specifically for PAH to improve treatment outcomes.

Other Applications:

Research on sildenafil has looked into additional uses outside those already mentioned. Studies have looked into how well it works for ailments like altitude sickness, Raynaud's phenomenon, and female sexual arousal dysfunction. In order to ascertain the efficiency and safety of Sildenafil in various patient populations, research in these areas is still being conducted.

Safety and Side Effects:

The safety profile and adverse effects of sildenafil have also been the subject of research. Potential negative effects include headaches, flushing, nasal congestion, and vision abnormalities have been studied. The goal of research has been to develop methods for reducing side effects and guaranteeing the safe use of Sildenafil in various patient populations.

Where to Buy Sildenafil

If you are looking to buy Sildenafil or liquid Viagra online for your research then look no further than Pinnacle Peptides. As a trusted supplier, we provide high-quality Sildenafil for scientific investigations. Researchers may trust Pinnacle Peptides to provide them with Sildenafil since they value consistency and quality in their products. We understand the importance of reliable and pure research materials, ensuring researchers have access to Sildenafil of the highest standards for their studies. It is crucial to keep in mind that Sildenafil for sale here is just meant for research and should not be used for human consumption or any other unauthorized applications.


The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.

Submit your review to Earn 50 Pinnacle Points click here to login

Write Your Own Review
You're reviewing:LIQUIVIA 25MG / ML | 60ML
Your Rating
DISCLAIMER: The products sold on this site are not a drug nor is it intended to treat, diagnose, cure or prevent any disease, nor is it meant for ANY cosmetic purpose. Pinnacle Peptides makes no claims of alleged beneficial properties of any product on this site if injected or ingested in any manner. Our Peptides are exclusively distributed legally within the laws of safe harbor for research peptides and are to be used for that purpose ONLY. If any country’s governing bodies feel we are in violation of their laws regarding peptides, we ask you contact us immediately via [email protected] so we may expeditiously rectify the situation.All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following:Their government regulations regarding the importation, purchase, possession and use of peptides. The health and safety hazards associated with the handling of peptides in a research setting. That peptides are NOT intended to be used as a food additive, drug, vitamin, supplement, cosmetic or any other inappropriate application. Such a sale would be otherwise denied.
Product List

Research Peptides

Research Chems

GLP-1 Peptides