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What Is HEXARELIN 5MG?
Hexarelin, also known as examorelin, is a synthetic analog of ghrelin that stimulates the production of growth hormone. It consists of 6 amino acids and is also related to growth hormone-releasing peptide-6 (GHRP-6). It has been shown to boost athletic performance, hence banned by the World Anti-Doping Agency (WADA).
Hexarelin was first synthesized in 1989 by a team of researchers at Tulane Medical School. It was developed to make a ghrelin analog that does not affect the release of insulin, glucagon and sex hormone. It is more potent and stable and has a longer half-life than ghrelin. Research shows that it preserves muscle mass, offers cardioprotection and promotes weight loss. At Pinnacle Peptides, hexarelin for sale is only available for research.
Structure Of HEXARELIN 5MG
IUPAC Name: L-histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide
Synonyms: Examorelin, Examorelin [INN]
Molecular Formula: C47H58N12O6
Molecular Weight: 887.0 g/mol
CAS number: 140703-51-1
PubChem CID: 6918297
Mechanism Of HEXARELIN 5MG
Hexarelin mimics the ghrelin actions. It binds to the growth hormone secretagogue/ghrelin receptor and stimulates the release of growth hormone. Plus, it has a slight effect on the release of adrenocorticotrophic hormone (ACTH), prolactin and cortisol. However, it does not affect FSH, LH, TSH and blood glucose levels.
1. Muscle Preservation
Hexarelin stimulates the release of growth hormone, which in turn promotes protein synthesis, reduces muscle breakdown, and causes cells to differentiate and proliferate. Literature shows that hexarelin can preserve muscle mass.
In one study, researchers induced cachexia (muscle loss) in rats using cisplatin. The rats were divided into two groups: one received a placebo (the control group), while the other group was treated with hexarelin. The results indicated that the control group experienced mitochondrial dysfunction and muscle atrophy. On the other hand, the treatment group showed resistance to muscle loss and maintained muscle strength. Furthermore, it was suggested that the improved mitochondrial function and reduced inflammatory processes contributed to this effect of hexarelin .
2. Weight Loss
Hexarelin has been shown to improve fat metabolism via its action at the CD36 receptor. A study was conducted to check the impact of hexarelin on body weight in nonobese insulin-resistant MKR mice and its corresponding wild-type FVB mice. The subjects were randomized to receive peritoneal injection of hexarelin or placebo two times a day for 12 days, Researchers found that hexarelin decreased liver and plasma triglyceride levels. Further, it also improved glucose levels and insulin tolerance. Additionally, the study found that hexarelin achieved this effect by improving lipid metabolism and increasing the adipocyte differentiation of white adipose tissues. These findings indicate that hexarelin might prove to be effective in treating lipid disorders .
Scientific literature shows that hexarelin has the potential to prevent cardiac remodeling and myocardial infarction. One study examined the cardioprotective effect of hexarelin in spontaneously hypertensive rats. Subjects aged 16 weeks were treated with either hexarelin alone or the combination of hexarelin and GHS-R antagonist for 5 weeks. The results found that hexarelin reduced cardiac fibrosis through decreasing myocardial collagen deposition and myocardial hydroxyproline content. It also suppressed the expression of collagen I and III and accelerated the degradation of collagen through the regulation of metalloproteinase II. Additionally, it relieved left ventricular hypertrophy, reduced high blood pressure, and improved left ventricular function .
Another study was conducted to examine the cardioprotective of hexarelin in rats. In this research, radioactive hexarelin was used to label the cardiac membrane of the rats. The researchers isolated a binding protein of Mr 84 000 similar to rat CD36. They found that activation of CD36 by hexarelin led to a dose-dependent increase in coronary perfusion pressure. On the other hand, this effect was absent in mice lacking the binding protein, suggesting that CD36 may play a role in inducing coronary vasospasm in conditions like atherosclerosis and hypercholesterolemia .
One more study investigated the mechanisms underlying the cardioprotective effect of hexarelin. Researchers induced heart failure resulting from myocardial infarction in rats by permanently ligating the coronary artery. These rats were either given a placebo or received 100ug/kg of hexarelin twice a day for 30 days. Hexarelin enhanced contractile function, reduced oxidative stress, fibrosis, apoptosis, and decreased histopathological damage. These positive effects were attributed to the up-regulation of eNOS (endothelial nitric oxide synthase) and an increase in serum nitric oxide (NO) concentrations, suggesting that eNOS could be a potential therapeutic target for addressing heart failure ./p>
Furthermore, hexarelin can also prevent myocardial damage induced by diabetes. One study in a rat model of diabetes found that hexarelin can reverse the negative changes associated with action potential duration, cell contraction and potassium currents. Further, it was also shown to reduce apoptotic signals and enhance GHS receptor expression .
Hexarelin is a synthetic analog of ghrelin and stimulates the release of growth hormone. It has been shown to promote heart health and prevent myocardial infarction and cardiac remodeling. Further, it aids weight loss and preserves muscle mass. It hasn’t been approved by the FDA yet and is also banned by the WADA. We don’t support its unwarranted use and offer hexarelin purchase exclusively for research. Only buy hexarelin if you are an authorized researcher.
- Sirago, G., et al., Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia. Sci Rep, 2017. 7(1): p. 13017.
- Mosa, R., et al., Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice. Endocrinology, 2017. 158(10): p. 3174-3187.
- Xu, X., et al., Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat. American Journal of Physiology-Heart and Circulatory Physiology, 2012. 303(6): p. H703-H711.
- Bodart, V., et al., CD36 Mediates the Cardiovascular Action of Growth Hormone-Releasing Peptides in the Heart. Circulation Research, 2002. 90(8): p. 844-849.
- Barnes, P., Cardioprotective role of myocardial endothelial nitric oxide synthase and serum nitric oxide induced by hexarelin in rats with myocardial infarction-induced heart failure. 2021: p. 395.
- Zhang, X., L. Qu, L. Chen, and C. Chen, Improvement of cardiomyocyte function by in vivo hexarelin treatment in streptozotocin-induced diabetic rats. Physiological Reports, 2018. 6(4): p. e13612.
Certificate of Analysis (COA)
High Performance Liquid Chromatography (HPLC)
What is Hexarelin?
Hexarelin is a synthetic peptide composed of six amino acids that fall under the category of growth hormone secretagogues. Its purpose is to encourage the pituitary gland to release growth hormones. When Hexarelin interacts with the ghrelin receptor, signaling events are set off, ultimately increasing growth hormone production. This peptide has drawn interest in laboratory and clinical settings due to its potential use in fostering muscle growth, improving recovery, and researching disorders linked to growth hormones.
Scientific study has focused a lot of interest on the synthetic peptide Hexarelin. Its main research areas are examined here, along with its effects and possible uses.
Stimulation of Growth Hormone Release:
Hexarelin's capacity to increase growth hormone (GH) secretion is one of the main areas of interest for study. The ghrelin receptor in the hypothalamus and pituitary gland is where Hexarelin binds. This binding starts a signaling chain reaction that boosts GH secretion. Its dose-response relationship and effectiveness in fostering GH release have been thoroughly investigated by researchers in vitro and animal experiments.
Muscle Growth and Performance Enhancement:
Hexarelin has shown promise for stimulating muscle development and improving athletic performance. As GH is essential for protein synthesis and muscle repair, its capacity to promote GH secretion contributes to its anabolic effects. Hexarelin administration has been demonstrated in studies to improve muscle strength, increase muscle mass, and speed up recovery from exercise-induced muscle injury. This peptide has been researched for its possible utility in improving athletic performance and treating diseases that cause muscle wasting.
Research on Hexarelin has looked at possible cardiovascular advantages. According to studies, Hexarelin may have cardioprotective effects by promoting blood vessel growth, lowering inflammation, and improving heart function. Hexarelin has the potential to enhance cardiac function and defend against heart injury, according to research done on animal models. More research is required to understand the underlying mechanisms and evaluate their possible clinical applications.
Recent studies imply that Hexarelin may have neuroprotective qualities. Studies have shown that it has the potential to safeguard neurons, improve cognitive function, and stimulate neurogenesis. Its neuroprotective effects are influenced by its impact on brain-derived neurotrophic factor (BDNF) levels and its capacity to induce the production of GH. Hexarelin is being studied as a potential therapy for neurodegenerative conditions like Parkinson's and Alzheimer's.
Additionally investigated for its effects on metabolism is Hexarelin. According to research, this peptide may boost lipolysis (the breakdown of fat) and promote glucose metabolism. Studies on obesity, insulin resistance, and metabolic syndrome are drawn to it because of its beneficial effects on metabolism. Researchers are investigating its potential therapeutic uses in altering body weight and metabolic parameters.
Unlike GHRP-6, Hexarelin isn't readily degraded by proteolytic enzymes, ensuring a growth hormone-mimicking effect that lasts longer. Out of the small peptides that trigger growth hormone release, Hexarelin is considered the strongest. A major hike in the levels of naturally produced cortisol and prolactin can also be noticed after administering Hexarelin 2mg. This peptide dose is supposed to be maintained for a year and a half. The amount is supposed to be distributed into 25-50 mcg 1-5 times a day. The administration of this peptide is suggested through the subcutaneous route.
Where to Buy Hexarelin
If you want to purchase Hexarelin online for your research, look no further than Pinnacle Peptides. Keep up the accurate results for your experiments with Hexarelin buy from Pinnacle Peptides. Hexarelin for sale here can extend the same quality of effects as Growth Hormone and IGF-1. To keep your research projects on schedule, we prioritize client happiness and offer rapid shipping—Trust Pinnacle Peptides with your peptides requirements to maximize the utility of this peptide in your research.
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