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Overview
The chemicals/materials for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.

What Is ALBUTEROL 5MG / ML 60ML?

Albuterol, also known as salbutamol, is a short-acting beta-2 adrenergic agonist primarily used for the treatment of bronchospasm in reversible chronic obstructive pulmonary disease (COPD). It has also been used for the adjuvant treatment of hyperkalemia. It was first developed by a British Pharmaceutical company named Allen and Henbury’s in 1962. Later, the FDA approved it for medical use in 1982. Currently, it is being researched for its effect on IgE-mediated abdominal pain and walking capacity related to motor fatigue. At Pinnacle Peptides, albuterol for sale is exclusively available for research and experimentation.

Structure Of ALBUTEROL 5MG / ML 60ML

From Pubchem

 

IUPAC Name: 4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol
Synonyms: Salbutamol, Proventil, Ventoline
Molecular Formula: C13H21NO3
Molecular Weight: 239.31 g/mol
CAS number: 18559-94-9
PubChem CID: 2083

Mechanism Of ALBUTEROL 5MG / ML 60ML

Research shows that salbutamol has a minimal effect on beta-1 adrenergic receptors that are present in the heart. It selectively binds to the beta-2 adrenergic receptors present in the smooth muscles of bronchioles. Stimulation of beta-2 receptors leads to the activation of adenyl cyclase which raises the intracellular concentration of cyclic AMP (cAMP). The increased cAMP suppresses the phosphorylation of myosin protein and decreases Ca+2 levels in the cell, resulting in the relaxation of bronchiole muscles. Furthermore, research suggests that increased cAMP decreases the release of hypersensitivity mediators from mast cells [1].

Pre-Clinical/Clinical Research

1. Spinal Muscular Atrophy

Spinal Muscular Atrophy (SMA) is a neuromuscular disorder that is characterized by degeneration of neurons in the spinal cord and brainstem. It is caused by a mutation in the SMN1 gene that is responsible for the expression of survival motor protein. This protein is involved in maintaining the health and function of neurons. In SMA, patients have insufficient levels of survival motor neuron protein, resulting in loss of neurons and skeletal muscle wasting.

Although people with SMA have malfunctioning SMN1 gene, they retain a closely related gene called SMN2. Both genes code for SMN protein, but SMN2 produces minimum quantity of the functional protein. A study found that that albuterol can increases the expression of SMN2 in patients with SMA [2]. Furthermore, it has been shown to increase the strength of inspiratory muscles and motor function in pediatrics suffering from SMA [3].

2. Bronchospasm

Salbutamol has been used to relieve bronchospasm induced by asthma, allergy, exercise and other causes. Recently, a study was designed to evaluate the safety and effectiveness of albuterol spray on COPD patients under general anaesthesia. 120 smoking patients were made to inhale two puffs of albuterol spray or a placebo in a randomized manner 20 minutes before general anesthesia, after completion of surgery and before extubation. The findings indicated that participants who took albuterol experienced a reduction in recurrent coughing and whooping compared to the placebo group [4].

Albuterol is a commonly used therapy for critical asthma, and some of its formulations contain benzalkonium chloride as a preservative. Research shows that benzalkonium chloride is associated with bronchospasm and results in poor outcomes. However, one recently published cohort study found that albuterol formulations containing benzalkonium chlorides are safe and effective for continuous nebulizations in critically ill children [5].

3. Transient Tachypnea

Transient tachypnea is a common respiratory condition that affects newborn babies within the first few hours after birth. It is characterized by rapid and shallow breathing that is developed due to delayed clearance of fluid in fetal lungs. Beta-2 adrenergic agonists have been shown to accelerate the clearance of fluid from alveoli, and they might have the potential to alleviate respiratory distress in newborns. One study found that salbutamol reduced the hospitalization stay and ventilation support in infants with transient tachypnea. Furthermore, it lowered TTN score, decreased FiO2 and respiratory rate and improved PaO2 [6].

4. IgE-mediated Food Allergy Abdominal Pain

Abdominal pain is one of the most frequent symptoms associated with IgE-mediated food allergy. The gastrointestinal tract is the second most affected system by anaphylaxis to food allergens after the skin. However, there are limited therapeutic options to relieve the symptoms. Experts think that the relaxation of visceral smooth muscles through beta-2 agonists might be effective for the alleviation of abdominal pain.

Recently, a retrospective study was designed to check the safety and efficacy of salbutamol on IgE-mediated food allergy. Researchers identified a group of patients who experienced abdominal pain during food allergy and compared the time it took for improvement between those who took salbutamol and the control group. The results found that treatment group experienced significant and faster improvement, approximately 12.5 minutes, compared to the control group (65 minutes) [7].

5. Cystic Fibrosis

Cystic Fibrosis is a genetic disorder that causes increased production of mucus in the airways, leading to the obstruction of respiratory passageways and lung infections. As a bronchodilator, salbutamol relaxes bronchioles and opens up airways, making breathing easier. One study found that albuterol improved FEV1 by 8% in 75% of the patients as compared to the control group (24%). Researchers also observed that change in lung function throughout the day was more significant in the treatment group than in the control group [8].

Summary

Albuterol is a beta-2 short acting adrenergic agonist. It relaxes the smooth muscles in the bronchioles and alleviates bronchospasm. It is FDA approved drug for the treatment of bronchospasms induced by exercise, asthma and other possible causes. Researcher shows that it might be helpful to alleviate abdominal pain induced by IgE mediated food allergy. Furthermore, it has been shown to improve cystic fibrosis, transient tachypnea and spinal muscular atrophy. However, we need further research to confirm these effects. We don’t support its unwarranted use and offer albuterol purchase exclusively for research and experimentation. Only buy albuterol if you are a qualified researcher.

References

  1. Johnson DB, Merrell BJ, Bounds CG. Albuterol. [Updated 2022 Sep 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:
  2. Tiziano, F.D., et al., Salbutamol increases survival motor neuron (SMN) transcript levels in leucocytes of spinal muscular atrophy (SMA) patients: relevance for clinical trial design. J Med Genet, 2010. 47(12): p. 856-8.
  3. Khirani, S., et al., Effect of Salbutamol on Respiratory Muscle Strength in Spinal Muscular Atrophy. Pediatr Neurol, 2017. 73: p. 78-87.e1.
  4. Maddah, S.A. and A. Barzegari, The Effect of Albuterol Spray on Hypoxia and Bronchospasm in Patients with Chronic Obstructive Pulmonary Disease (COPD) under General Anesthesia: A bouble-Blind Randomized Clinical Trial. Ethiop J Health Sci, 2023. 33(3): p. 491-498.
  5. Al-Subu, A.M., et al., Effectiveness and Safety of Albuterol Solutions With and Without Benzalkonium Chloride. Respiratory Care, 2023. 68(6): p. 734-739.
  6. Talaat, A.A., et al., Evaluation of inhaled beta-2 agonist in management of transient tachypnea of the newborn. Bulletin of the National Research Centre, 2020. 44(1): p. 12.
  7. Frugier, C., et al., Potential Efficacy of High-Dose Inhaled Salbutamol for the Treatment of Abdominal Pain During Oral Food Challenge. J Allergy Clin Immunol Pract, 2021. 9(8): p. 3130-3137.
  8. Hordvik, N.L., et al., The effects of albuterol on the lung function of hospitalized patients with cystic fibrosis. American Journal of Respiratory and Critical Care Medicine, 1996. 154(1): p. 156-160.
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DISCLAIMER: The products sold on this site are not a drug nor is it intended to treat, diagnose, cure or prevent any disease, nor is it meant for ANY cosmetic purpose. Pinnacle Peptides makes no claims of alleged beneficial properties of any product on this site if injected or ingested in any manner. Our Peptides are exclusively distributed legally within the laws of safe harbor for research peptides and are to be used for that purpose ONLY. If any country’s governing bodies feel we are in violation of their laws regarding peptides, we ask you contact us immediately via [email protected] so we may expeditiously rectify the situation.All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following:Their government regulations regarding the importation, purchase, possession and use of peptides. The health and safety hazards associated with the handling of peptides in a research setting. That peptides are NOT intended to be used as a food additive, drug, vitamin, supplement, cosmetic or any other inappropriate application. Such a sale would be otherwise denied.
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