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Overview
The chemicals/materials for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.

What Is SARM's S4 ANDARINE 50MG / ML | 60ML?

Andarine, also known as S4, is a non-steroidal selective androgen receptor modulator (SARM). Research shows that its anabolic activity is similar to that of testosterone’s. It was initially discovered by a pharmaceutical company named GTx, Inc. for musculoskeletal disorders and benign prostatic hyperplasia. Later, it was found to improve fertility and sexual health in men and women. It has not been approved by the FDA yet. Further, it is banned by the World Anti-Doping Agency because of its misuse by athletes to enhance performance. At Pinnacle Peptides, S4 andarine for sale is exclusively available for research.

Structure Of SARM's S4 ANDARINE 50MG / ML | 60ML

From Pubchem

 

IUPAC Name: (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Synonyms: 401900-40-1, GTX-007, S-4 cpd
Molecular Formula: C19H18F3N3O6
Molecular Weight: 441.4 g/mol
CAS number: 401900-40-1
PubChem CID: 9824562

Mechanism Of SARM's S4 ANDARINE 50MG / ML | 60ML

As a SARM, andarine has been shown to target androgen receptors (AR) in selective tissues. It has been shown to affect receptors in bones and muscles without exerting any effect on prostate tissues. Research suggests that it is rapidly absorbed in the bloodstream after oral intake. It binds with high affinity (Ki=7.5 nM) to AR and exhibits agonist action. In bones, it has been shown to inhibit bone turnover, increase bone mineral density.

Pre-Clinical/Clinical Research

1. Fat Loss

S4 andarine has been shown to induce fat loss in animal models. One study was conducted to check the effect of andarine on fat loss in rats. The subjects were randomly administered S4 or placebo for 120 days. Researchers observed that the treatment group experienced a significant reduction in body fat as compared to the control group [1]. It is believed that the fat loss effect of this SARM might be related to the ability to increase muscle mass. The metabolic rate of the body increases with muscle mass, resulting in increased energy expenditure and fat utilisation.

2. Cancer

Literature reveals that Andarine might have the ability to inhibit tumor growth. The androgen receptor has been shown to be associated with the development of pancreatic cancer. Hence, SARMs might prove effective in treating pancreatic cancer. One study found that andarine suppressed growth and proliferation in pancreatic cancer cells through cell cycle arrest at the G0/G1 phase. It was observed to downregulate the expression of CDKN1A, a gene involved in regulating cell cycle and proliferation. Furthermore, it also found that the PI3/AKT/mTOR pathway is not involved in the carcinogenic effects of S4 on pancreatic cancer [2].

Similarly, andarine shows anticarcinogenic effects on lung cancer by inhibiting cell growth and proliferation and promoting apoptosis. Research suggests that it might suppress certain genes associated with antitumor activity [3]. Similarly, in the context of hepatocellular carcinoma (HCC), researchers found that Andarine inhibits HCC by targeting the PI3K/AKT/mTOR pathway, a frequently activated signaling pathway involved in the severity of HCC [4].

3. Muscle Mass

Literature supports the evidence that S4 can boost muscle mass and increase strength. In a study involving castrated male rats, researchers assessed the effects of S4 on skeletal muscles. The procedure of castration led to a reduction in androgen levels in the subjects. After twelve weeks of castration, the rats were administered either S4, testosterone, or a placebo. The treatment group exhibited a restoration in mass and strength of the soleus and levator ani muscles, comparable to levels in intact animals.

Furthermore, S4 had a minor impact (only 16 to 17%) on seminal vesicles as compared to dihydrotestosterone (50%). [5]. Another study found that Andarine S4 displayed selective activity by preferentially stimulating anabolic organs compared to androgenic tissues. Additionally, it revealed that the anabolic activity of S4 was similar to or greater than that of testosterone propionate [6].

4. Bone Mineral Density

Andarine positively impacts bone mineral density and might offer a promising treatment for osteoporosis. Estrogen levels decline with advancing age and contribute to bone weakness [7]

One study was conducted to check the impact of S4 on ovariectomized rats. These rats underwent a procedure for the removal of ovaries, that reduced estrogen levels in their body. Subsequently, they were treated with either placebo or andarine. The results found that the treatment group exhibited a significant improvement in bone mineral density and bone cortical quality. Furthermore, S4 was shown to increase the load-bearing capacity of the bone [8].

Summary

S4 is a selective androgen receptor modulator (SARM). It exerts anabolic effects in bone and muscle tissues with efficacy comparable to testosterone without affecting prostate tissues. It has been shown to induce weight loss, build mass and prevent bone loss. Furthermore, research suggests that it exhibits anticarcinogenic effects. It is often abused by athletes to enhance sports performance. However, further research is needed to validate these effects. We don’t encourage its unwarranted use and offer S4 andarine purchase exclusively for research. Only buy S4 andarine if you are a licensed researcher.

References

  1. Kearbey, J.D., et al., Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharm Res, 2007. 24(2): p. 328-35.
  2. Bölük, A., et al., In vitro anti-carcinogenic effect of andarine as a selective androgen receptor modulator on MIA-PaCa-2 cells by decreased proliferation and cell-cycle arrest at G0/G1 phase. Biochem Biophys Res Commun, 2023. 671: p. 132-139.
  3. Demircan, T., M. Yavuz, and A. Bölük, Andarine Plays a Robust In-vitro Anti-carcinogenic Role on A549 Cells Through Inhibition of Proliferation and Migration, and Activation of Cell-cycle Arrest, Senescence, and Apoptosis. 2023.
  4. Yavuz, M., L.S. Takanlou, B. Avcı Ç, and T. Demircan, A selective androgen receptor modulator, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling pathway. Gene, 2023. 869: p. 147390.
  5. Gao, W., et al., Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology, 2005. 146(11): p. 4887-97.
  6. Yin, D., et al., Pharmacodynamics of Selective Androgen Receptor Modulators. Journal of Pharmacology and Experimental Therapeutics, 2003. 304(3): p. 1334-1340.
  7. Kearbey, J.D., et al., Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharm Res, 2007. 24(2): p. 328-35.
  8. Kearbey, J.D., et al., Effects of selective androgen receptor modulator (SARM) treatment in osteopenic female rats. Pharm Res, 2009. 26(11): p. 2471-7.

Certificate of Analysis (COA)

COA

High Performance Liquid Chromatography (HPLC)

HPLC

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