What Is BPC-157 5MG?
BPC-157 stands for body protection compound 157. It is a synthetic compound composed of 15 amino acids derived from a protein called body protection compound found in human gastric juice. It plays a significant role in preserving the lining of gastric tissues.
Its history dates back to the late 1990s when it was studied by a group of researchers in Croatia. Their initial research was focused on its ability to promote ulcer healing. Later, it gained popularity in the fitness community due to its potential to enhance tissue recovery and performance. It is not approved by the FDA for clinical use. At Pinnacle Peptides, BPC-157 purchase is limited to research purposes only, not for human consumption.
Structure Of BPC-157 5MG
From Pubchem
Synonyms: BPC-15, Booly protection compound 15
Molecular Formula: C62H98N16O22
Molecular Weight: 1419.5 g/mol
Sequence: GEPPPGKPADDAGLV
CAS number: 137525-51-0
PubChem CID: 108101
Mechanism Of BPC-157 5MG
Its mechanism of action is not clear. However, research shows that it promotes the formation of blood vessels by stimulating vascular endothelial growth factor. Further, it inhibits 4-hydroxynoneal, a molecule produced in the body that negatively impacts cellular growth. Plus, it stimulates the formation of fibroblasts and upregulates the expression of multiple growth receptors.
Pre-Clinical/Clinical Research
1. Wound Healing
Plenty of research on animal models shows that BPC-157 promotes wound healing. One study found that the intraperitoneal delivery of BPC-157 at a dose of 2 micrograms per kilogram enhanced motor function, diminished white and gray matter lesions and alleviated neuronal damage in rats with spinal cord injury [1].
Another study investigated the impact of BPC-157 in rats with acute or chronic gastric ulcers. The results found that BPC-157 dosage through intranasal or intragastric dose reduced ulcer size and enhanced the healing process. Plus, it was also found to promote the rebuilding of glandular epithelium and tissue promotion [2].
Furthermore, BPC-157 has been shown to accelerate wound closure in the alkali-burn rat model. The potential mechanism for this effect includes the deposition of collagen through the ERK1/2 signaling pathway, re-epithelialization and glandular tissue formation [3].
2. Neuroprotection
BPC-157 has been shown to promote neuroprotection. One study found that the intraperitoneal administration of BPC-157 counteracted the effects of MTPT, an agent used to induce damage caused by Parkinson’s disease. It reduced motor abnormalities, decreased hyperactivity and improved somatosensory orientation [4].
Similarly, one study performed on rats has revealed that BPC-157 possesses the ability to mitigate the impacts of cuprizone, a substance known to induce nerve fiber demyelination and damage associated with multiple sclerosis [5]. Furthermore, research shows that BPC-157 can improve memory and locomotion and ameliorate neuronal damage in rats with stroke. These findings suggest that this synthetic peptide might prove to be a useful drug for nervous system disorders [6].
3. Angiogenesis
Numerous studies suggest that BPC-157 promotes angiogenesis, the formation of new blood vessels. In a study, rats with ischemic colitis were administered BPC-157 at a dosage of 10 micrograms per kilogram. The results found that BPC-157 rapidly restored blood supply in the affected region [7].
Another study was conducted on rats in which researchers ligated the inferior vena cava vein to disrupt blood flow, leading to vessel injury and thrombus formation. The results found that BPC-157 treatment caused the redistribution of trapped blood volume and counteracted these effects [8].
The angiogenic effects of BPC-157 may be attributed to the activation of VEGFR2, a cell surface receptor that plays a role in the nitric oxide (NO) signaling pathway. In a study involving rats with hind limb ischemia, BPC-157 treatment was found to increase the expression of VEGFR2, subsequently activating the VEGFR2-Akt-eNOS pathway. Conversely, the administration of dynasore, an inhibitor of VEGFR2, failed to activate the pathway and inhibited endothelial tube formation [9].
4. Recovery of musculoskeletal injuries
Studies on animal models suggest that BPC-157 exhibits the potential to enhance performance and accelerate recovery from injuries. In one study, BPC-157 was administered via intraperitoneal, oral, or topical route following surgical resection in rats. The results indicated improved healing of transected medial collateral ligaments, suggesting that BPC-157 may hold promise for enhancing the recovery of acute ligament injuries [10].
Another study was conducted to suggest the potential mechanism by which BPC-157 enhance the healing process of injured tendons. The findings revealed that BPC-157 accelerated the outgrowth of tendon fibroblasts, enhanced the survival of these cells under H2O2-induced stress, and promoted the migration and spreading of tendon fibroblasts in a dose-dependent manner. Additionally, increased expression of FAk and paxillin was observed, suggesting that these proteins may play a role in mediating the recovery of injured tendons [11].
Furthermore, BPC-157 has shown effectiveness in speeding up the recovery from transected muscle injuries and muscle-crushing injuries in rats. Additionally, it has been shown to mitigate the adverse effects of corticosteroids on tendon-to-bone healing [12].
Summary
Studies on animal models suggest that BPC-157 has the potential to accelerate wound healing and recovery of musculoskeletal injuries. It promotes angiogenesis and possesses the ability to offer neuroprotection. However, most of the studies are done on animal models. We need studies on humans to establish its safety and efficacy. As an experimental drug, BPC-157 for sale is only available for research and educational purposes. We don’t support its unwarranted use and encourage you to buy BPC-157 only to support your research.
References
- Perovic, D., et al., Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. Journal of Orthopaedic Surgery and Research, 2019. 14(1): p. 199.
- Xue, X.C., et al., Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World J Gastroenterol, 2004. 10(7): p. 1032-6.
- Huang, T., et al., Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Des Devel Ther, 2015. 9: p. 2485-99.
- Klicek, R., et al., Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability. J Physiol Pharmacol, 2013. 64(5): p. 597-612.
- Klicek, R., et al., Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability. J Physiol Pharmacol, 2013. 64(5): p. 597-612.
- Vukojevic, J., et al., Pentadecapeptide BPC 157 and the central nervous system. Neural Regen Res, 2022. 17(3): p. 482-487.
- Duzel, A., et al., Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights. World J Gastroenterol, 2017. 23(48): p. 8465-8488.
- Vukojević, J., et al., Rat inferior caval vein (ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157. Vascul Pharmacol, 2018. 106: p. 54-66.
- Hsieh, M.-J., et al., Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. Journal of Molecular Medicine, 2017. 95(3): p. 323-333.
- Klicek, R., et al., Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability. J Physiol Pharmacol, 2013. 64(5): p. 597-612.
- Sikiric, P., et al., A behavioural study of the effect of pentadecapeptide BPC 157 in Parkinson's disease models in mice and gastric lesions induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydrophyridine. J Physiol Paris, 1999. 93(6): p. 505-12.
- Vukojevic, J., et al., Pentadecapeptide BPC 157 and the central nervous system. Neural Regen Res, 2022. 17(3): p. 482-487.
Certificate of Analysis (COA)
High Performance Liquid Chromatography (HPLC)
Mass Spectrometry (MS)
-
Always legit and fast shippingLove this place. Products are always legit and I get my stuff in 2 or 3 days max. Been ordering from Pinnacle foe years and have 100% trust in their goods and services.
Posted on
-
Excellent product and service!Definitely the best source for this stuff hands down! Very happy with the quality and delivery times.
Posted on
-
great experienceGreat products. Will be reordering next week.
Posted on
-
Hands down the bestNice site, fast shipping, superb quality. My new vendor for sure!
Posted on