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BACTERIOSTATIC WATER

For this product you will need: BACTERIOSTATIC WATER For reconstitution.

Overview
The chemicals/materials for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.

What Is MGF-PEG 2MG?

Pegylated mechano growth factor (PEG-MGF) is a variant of insulin-like growth factor-1 (IGF-1). As the name indicates, the drug undergoes the process of pegylation that involves attaching the molecule of polyethylene glycol (PEG) to MGF. This modification extends the half-life of the drug from minutes to days, thus ensuring sustained activity.

Research shows that PEG-MGF has the potential to enhance endurance, boost the immune system, decrease cholesterol levels, and reduce overall body fat. Animal studies reveal that PEG-MGF plays a role in the muscle's regeneration process by increasing protein synthesis and triggering the activation of satellite cells. PEG-MGF is not approved by the FDA for any medical or therapeutic applications. At Pinnacle Peptides, PEG-MGF for sale is exclusively available for research and educational institutions.

Structure Of MGF-PEG 2MG

From Pubchem

 

Synonyms: PEG IGF-1 Ec, PEG myotrophin, Pegylated MGF,
Molecular Formula: C121H200N42O39
Sequence: PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-Cys
CAS number: 307297-39-8
PubChem CID: 178101669

Mechanism Of MGF-PEG 2MG

MGF, as a variant of IGF-1, binds to the IGF-1 receptor (IGF-1R) that initiates a series of intracellular signaling events. This, in turn, leads to the activation of satellite cells that play an important role in the repair of damaged muscle fibers through proliferation, differentiation, and fusion with existing myofibers. This facilitates the hypertrophy of existing muscle fibers, thus increasing muscle mass. Furthermore, PEG-MGF stimulates the production of structural proteins within muscle cells. It has also been shown to enhance nitrogen retention in muscle tissue, fostering a positive nitrogen balance conducive to optimal muscle growth.

Pre-Clinical/Clinical Research

1. Skeletal Muscle

Sports-related muscle injuries, including strains and avulsion injuries, often require surgery. However, recovery can be lengthy with sub-optimal results. Research using a mouse model of muscle injury suggests that directly injecting MGF into the muscle may ameliorate impaired skeletal muscle regeneration by decreasing certain inflammatory hormone expression and reducing oxidative stress [1].

Another study has indicated that MGF stimulates the insulin-like growth factor 1 (IGF-1) receptor to a similar extent as IGF-1 [2]. Activation of this receptor has been associated with reduced aging, increased lean body mass, and improved energy balance in humans. This suggests that PEG-MGF may produce effects comparable to IGF-1, resulting in enhanced muscle repair, improved fat metabolism, and overall increases in lean body mass.

Studies conducted on mice reported that administration of MGF during exercise results in about a 25% rise in the average size of muscle fibers. However, it poses a practical challenge as it is difficult to administer MGF directly into individualized myocytes to achieve hypertrophy [3]. PEG-MGF addresses this limitation by extending the plasma half-life of MGF, allowing its delivery through a single intravenous injection instead of multiple intramuscular injections.

2. Neuroprotective Effect

A mice study found that high levels of MGF are associated with reduced age-related neuron degeneration. This, in turn, allowed the subjects to maintain their cognitive functions and exhibit peak cognitive performance for a long duration in old age. According to the study, the effectiveness of MGF in the brain is influenced by age. It found that the introduction of MGF expression earlier in life enhanced cognitive outcomes in the long run while the same treatment didn’t show any significant effect when administered in old age[4].

Furthermore, MGF has demonstrated efficacy in ameliorating muscle weakness and mitigating the loss of motor neurons in mouse models of ALS (Amyotrophic Lateral Sclerosis) [5]. The study suggests that MGF is naturally expressed in the brain after hypoxic injury and is overexpressed in areas where neuron regeneration is most pronounced.

3. Bone Repair and Growth

Research conducted on rabbits reported that PEG-MGF can accelerate the bone repair process by enhancing the proliferation of osteoblasts, the cells responsible for bone mineralization. Rabbits subjected to high doses of MGF exhibited a level of healing at four weeks equivalent to that observed in control groups after six weeks [6]. PEG-MGF holds a promising treatment for promoting bone healing, thus reducing the duration of immobilization necessary for effective recovery.

4. Dental Application

Research conducted on cell cultures of human periodontal ligament cells reported that PEG-MGF enhances osteogenic differentiation and increases the expression of MMP-1 and MMP-2. These factors improve the repairing of ligaments that connect the tooth to the bone [7]. This could potentially serve as an alternative to tooth extractions and implants, offering the possibility of retaining natural teeth after injury. There is even speculation that PEG-MGF might facilitate the preservation of damaged or avulsed teeth after surgical re-implantation.

5. Heart Diseases

Research indicates that PEG-MGF offers cardiovascular protection. In sheep studies, PEG-MGF safeguarded the heart muscle from ischemia (reduced blood supply) and enhanced heart function following myocardial infarction [8]. Another study suggested that PEG-MGF may decrease the risk of heart disease by preventing programmed cell death in heart muscle cells. Furthermore, it has shown the ability to regulate the migration and proliferation of stem cells in the heart, contributing to the growth and formation of human heart tissues [9]. In rat experiments, targeted administration of PEG-MGF improved cardiac function after a heart attack [10].

Summary

Pegylated mechano growth factor (PEG-MGF) is a variant of IGF-I with an increased half-life. Studies have reported that PEG-MGF has the potential to heal muscle injury, offer neuroprotection, boost bone repair, and improve dental health. Moreover, it has also been shown to promote cardiovascular protection following myocardial infarction. PEG-MGF is not an FDA-approved drug. We don’t support its unwarranted use and offer PEG-MGF purchase solely for research. Only buy PEG-MGF if you are a qualified researcher.

References

  1. Liu, X., et al., Impaired skeletal muscle regeneration induced by macrophage depletion could be partly ameliorated by MGF injection. Frontiers in Physiology, 2019. 10: p. 601.
  2. Janssen, J.A., et al., Potency of full-length MGF to induce maximal activation of the IGF-I R is similar to recombinant human IGF-I at high equimolar concentrations. PLoS One, 2016. 11(3): p. e0150453.
  3. Goldspink, G., Research on mechano growth factor: its potential for optimising physical training as well as misuse in doping. British journal of sports medicine, 2005. 39(11): p. 787-788.
  4. Walker, A. Hearts and Minds of Mice and Men: Mechano Growth Factor a new tool in the battle against age-related neuron loss? 2017; Available from:
  5. Dłużniewska, J., et al., A strong neuroprotective effect of the autonomous C‐terminal peptide of IGF‐1 Ec (MGF) in brain ischemia. The FASEB journal, 2005. 19(13): p. 1896-1898.
  6. Deng, M., et al., Mechano growth factor E peptide promotes osteoblasts proliferation and bone-defect healing in rabbits. International orthopaedics, 2011. 35: p. 1099-1106.
  7. Jing-tao, C., et al., Mechano-growth factor regulated cyclic stretch-induced osteogenic differentiation and MMP-1, MMP-2 expression in human periodontal ligament cells by activating the MEK/ERK1/2 pathway. Shanghai Journal of Stomatology, 2019. 28(1): p. 6.
  8. Carpenter, V., et al., Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. Heart, lung and circulation, 2008. 17(1): p. 33-39.
  9. Deng, M., et al., New proangiogenic activity on vascular endothelial cells for C-terminal mechano growth factor. Acta Biochim Biophys Sin, 2012. 44(4): p. 316-322.
  10. Peña, J.R., et al., Localized delivery of mechano-growth factor E-domain peptide via polymeric microstructures improves cardiac function following myocardial infarction. Biomaterials, 2015. 46: p. 26-34.

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COA

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