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The chemicals/materials for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.

What Is MGF-PEG 2MG?

Pegylated mechano growth factor (PEG-MGF) is a variant of insulin-like growth factor-1 (IGF-1). As the name indicates, the drug undergoes the process of pegylation that involves attaching the molecule of polyethylene glycol (PEG) to MGF. This modification extends the half-life of the drug from minutes to days, thus ensuring sustained activity.

Research shows that PEG-MGF has the potential to enhance endurance, boost the immune system, decrease cholesterol levels, and reduce overall body fat. Animal studies reveal that PEG-MGF plays a role in the muscle's regeneration process by increasing protein synthesis and triggering the activation of satellite cells. PEG-MGF is not approved by the FDA for any medical or therapeutic applications. At Pinnacle Peptides, PEG-MGF for sale is exclusively available for research and educational institutions.

Structure Of MGF-PEG 2MG

From Pubchem


Synonyms: PEG IGF-1 Ec, PEG myotrophin, Pegylated MGF,
Molecular Formula: C121H200N42O39
Sequence: PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-Cys
CAS number: 307297-39-8
PubChem CID: 178101669

Mechanism Of MGF-PEG 2MG

MGF, as a variant of IGF-1, binds to the IGF-1 receptor (IGF-1R) that initiates a series of intracellular signaling events. This, in turn, leads to the activation of satellite cells that play an important role in the repair of damaged muscle fibers through proliferation, differentiation, and fusion with existing myofibers. This facilitates the hypertrophy of existing muscle fibers, thus increasing muscle mass. Furthermore, PEG-MGF stimulates the production of structural proteins within muscle cells. It has also been shown to enhance nitrogen retention in muscle tissue, fostering a positive nitrogen balance conducive to optimal muscle growth.

Pre-Clinical/Clinical Research

1. Skeletal Muscle

Sports-related muscle injuries, including strains and avulsion injuries, often require surgery. However, recovery can be lengthy with sub-optimal results. Research using a mouse model of muscle injury suggests that directly injecting MGF into the muscle may ameliorate impaired skeletal muscle regeneration by decreasing certain inflammatory hormone expression and reducing oxidative stress [1].

Another study has indicated that MGF stimulates the insulin-like growth factor 1 (IGF-1) receptor to a similar extent as IGF-1 [2]. Activation of this receptor has been associated with reduced aging, increased lean body mass, and improved energy balance in humans. This suggests that PEG-MGF may produce effects comparable to IGF-1, resulting in enhanced muscle repair, improved fat metabolism, and overall increases in lean body mass.

Studies conducted on mice reported that administration of MGF during exercise results in about a 25% rise in the average size of muscle fibers. However, it poses a practical challenge as it is difficult to administer MGF directly into individualized myocytes to achieve hypertrophy [3]. PEG-MGF addresses this limitation by extending the plasma half-life of MGF, allowing its delivery through a single intravenous injection instead of multiple intramuscular injections.

2. Neuroprotective Effect

A mice study found that high levels of MGF are associated with reduced age-related neuron degeneration. This, in turn, allowed the subjects to maintain their cognitive functions and exhibit peak cognitive performance for a long duration in old age. According to the study, the effectiveness of MGF in the brain is influenced by age. It found that the introduction of MGF expression earlier in life enhanced cognitive outcomes in the long run while the same treatment didn’t show any significant effect when administered in old age[4].

Furthermore, MGF has demonstrated efficacy in ameliorating muscle weakness and mitigating the loss of motor neurons in mouse models of ALS (Amyotrophic Lateral Sclerosis) [5]. The study suggests that MGF is naturally expressed in the brain after hypoxic injury and is overexpressed in areas where neuron regeneration is most pronounced.

3. Bone Repair and Growth

Research conducted on rabbits reported that PEG-MGF can accelerate the bone repair process by enhancing the proliferation of osteoblasts, the cells responsible for bone mineralization. Rabbits subjected to high doses of MGF exhibited a level of healing at four weeks equivalent to that observed in control groups after six weeks [6]. PEG-MGF holds a promising treatment for promoting bone healing, thus reducing the duration of immobilization necessary for effective recovery.

4. Dental Application

Research conducted on cell cultures of human periodontal ligament cells reported that PEG-MGF enhances osteogenic differentiation and increases the expression of MMP-1 and MMP-2. These factors improve the repairing of ligaments that connect the tooth to the bone [7]. This could potentially serve as an alternative to tooth extractions and implants, offering the possibility of retaining natural teeth after injury. There is even speculation that PEG-MGF might facilitate the preservation of damaged or avulsed teeth after surgical re-implantation.

5. Heart Diseases

Research indicates that PEG-MGF offers cardiovascular protection. In sheep studies, PEG-MGF safeguarded the heart muscle from ischemia (reduced blood supply) and enhanced heart function following myocardial infarction [8]. Another study suggested that PEG-MGF may decrease the risk of heart disease by preventing programmed cell death in heart muscle cells. Furthermore, it has shown the ability to regulate the migration and proliferation of stem cells in the heart, contributing to the growth and formation of human heart tissues [9]. In rat experiments, targeted administration of PEG-MGF improved cardiac function after a heart attack [10].


Pegylated mechano growth factor (PEG-MGF) is a variant of IGF-I with an increased half-life. Studies have reported that PEG-MGF has the potential to heal muscle injury, offer neuroprotection, boost bone repair, and improve dental health. Moreover, it has also been shown to promote cardiovascular protection following myocardial infarction. PEG-MGF is not an FDA-approved drug. We don’t support its unwarranted use and offer PEG-MGF purchase solely for research. Only buy PEG-MGF if you are a qualified researcher.


  1. Liu, X., et al., Impaired skeletal muscle regeneration induced by macrophage depletion could be partly ameliorated by MGF injection. Frontiers in Physiology, 2019. 10: p. 601.
  2. Janssen, J.A., et al., Potency of full-length MGF to induce maximal activation of the IGF-I R is similar to recombinant human IGF-I at high equimolar concentrations. PLoS One, 2016. 11(3): p. e0150453.
  3. Goldspink, G., Research on mechano growth factor: its potential for optimising physical training as well as misuse in doping. British journal of sports medicine, 2005. 39(11): p. 787-788.
  4. Walker, A. Hearts and Minds of Mice and Men: Mechano Growth Factor a new tool in the battle against age-related neuron loss? 2017; Available from:
  5. Dłużniewska, J., et al., A strong neuroprotective effect of the autonomous C‐terminal peptide of IGF‐1 Ec (MGF) in brain ischemia. The FASEB journal, 2005. 19(13): p. 1896-1898.
  6. Deng, M., et al., Mechano growth factor E peptide promotes osteoblasts proliferation and bone-defect healing in rabbits. International orthopaedics, 2011. 35: p. 1099-1106.
  7. Jing-tao, C., et al., Mechano-growth factor regulated cyclic stretch-induced osteogenic differentiation and MMP-1, MMP-2 expression in human periodontal ligament cells by activating the MEK/ERK1/2 pathway. Shanghai Journal of Stomatology, 2019. 28(1): p. 6.
  8. Carpenter, V., et al., Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. Heart, lung and circulation, 2008. 17(1): p. 33-39.
  9. Deng, M., et al., New proangiogenic activity on vascular endothelial cells for C-terminal mechano growth factor. Acta Biochim Biophys Sin, 2012. 44(4): p. 316-322.
  10. Peña, J.R., et al., Localized delivery of mechano-growth factor E-domain peptide via polymeric microstructures improves cardiac function following myocardial infarction. Biomaterials, 2015. 46: p. 26-34.

Certificate of Analysis (COA)


What is MGF PEG?

MGF PEG or Pegylated Mechano growth factor is a synthetic version of IGF-1. The modified form of the naturally occurring Mechano Growth Factor (MGF) is known as MGF PEG (Mechano Growth Factor Polyethylene Glycol). It is made by joining a polyethylene glycol (PEG) molecule to MGF, extending its biological half-life. MGF PEG is well known for its function in repairing and growing muscle. It functions by assisting muscle stem cells in activating and proliferating, which improves muscular hypertrophy and recovery. Long-lasting anabolic effects are produced by the sustained release of growth factor made possible by MGF PEG's increased half-life. The ability of MGF PEG 2mg to induce changes in elderly people who have significantly lost muscle mass over the years was discovered when the researchers studied it in vitro. Regular usage of MGF PEG can cure the dystrophy that aging causes in the muscle fibers. IGF-1 and this peptide collaborate to produce results. IGF-1, which is present in skeletal muscles, can quickly restore the functionality of muscles that have sustained significant injury. This peptide actively contributes to the adult brain's physiological well-being. Researchers are looking into the potential therapeutic uses of MGF PEG for the treatment of injuries, the rehabilitation from injuries, and the improvement of muscular performance. Like IGF-1, this peptide plays an essential role in the regeneration of skeletal muscle fibres and neurons.

MGF PEG Research

The synthetic peptide known as MGF PEG (Mechano Growth Factor Polyethylene Glycol) has received a lot of attention from scientists. The main areas of MGF PEG research are examined here, along with its results and possible applications.

Enhanced Muscle Growth and Hypertrophy:

The promotion of muscle growth and hypertrophy is one of the main areas of MGF PEG research. Increased protein synthesis and the development of new muscle fibers are the results of MGF PEG's stimulation of the activation and proliferation of muscle stem cells. MGF PEG's effects on muscle growth have been investigated using a variety of techniques, including in vitro and animal research. They look into its ability to increase muscle mass, strength, and performance as well as its function in preventing diseases that cause muscle wasting.

Muscle Repair and Regeneration:

Research on MGF PEG also examines how it affects muscle regeneration and repair. According to studies, MGF PEG can speed up regeneration by encouraging the activation of satellite cells, which are in charge of muscle repair. It encourages the growth of fresh muscle fibers, hastening the healing of damaged or injured muscles. The mechanisms underpinning MGF PEG's regenerative properties and its potential therapeutic uses in the repair and regeneration of muscle injuries are being studied by researchers.

Anabolic Signaling Pathways:

The study of MGF PEG has concentrated on identifying the molecular mechanisms and signaling routes through which it exerts its anabolic effects. MGF PEG's interactions with growth factor receptors, intracellular signaling molecules, and gene expression patterns related to muscle growth and repair have all been investigated in studies. Understanding these pathways can help discover targets for new treatment approaches and can help maximize the efficiency of MGF PEG.

Combating Muscle Wasting Conditions:

The possible application of MGF PEG in fighting muscle wasting ailments is another topic of inquiry. Studies on ailments such muscle atrophy, sarcopenia, and particular neuromuscular illnesses have showed potential with MGF PEG. Researchers are looking into its potential to prevent muscle wasting, boost muscle function, and improve overall muscle health. The objective is to create methods that make use of MGF PEG to lessen the consequences of muscle wasting and enhance quality of life for affected people.

Dosing, Delivery, and Safety:

MGF PEG research also focuses on enhancing dosage schedules, delivery techniques, and evaluating this peptide's safety profile. Studies seek to identify the best MGF PEG dosage, frequency, and duration for maximizing its advantages while reducing any potential negative effects. To increase the bioavailability and stability of MGF PEG, researchers investigate a range of administration methods, including injectable formulations. For MGF PEG to be used safely and responsibly, research on the long-term effects and potential hazards associated with its use is essential.

Where to Buy MGF PEG

Pinnacle Peptides can be lucky spot for researchers who wish to buy MGF PEG online. If you are looking to purchase MGF PEG for research purposes, We are the reputable supplier that offers high-quality peptides. Pinnacle Peptides specializes in providing peptides for scientific research and maintains strict quality control measures to ensure product purity and integrity. We offer MGF PEG for sale and other research peptides that can be conveniently ordered online. With a focus on customer satisfaction, we strive to deliver reliable products and exceptional service to researchers in need of peptide compounds for their studies.


The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.

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