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What Is SERMORELIN 5MG?
Sermorelin is a man-made analog of growth hormone-releasing hormone (GHRH). It is the shortest synthetic peptide comprised of 29 amino acids that can produce biological activity. In the past, it served as a means for treating and diagnosing growth hormone deficiency in children. Currently, it is being researched for its role in sleep quality, cardiac remodeling, brain tumor and lipodystrophy. At Pinnacle Peptide, sermorelin for sale is exclusively available for research and experimentation.
Structure Of SERMORELIN 5MG
Synonyms: Sermorelina, 86168-78-7, Somatoliberin
Molecular Formula: C149H246N44O42S
Molecular Weight: 3357.9 g/mol Sequence: YADAIFTNSYRKVLGQLSARKLLQDIMSR
CAS number: 86168-78-7
PubChem CID: 16132413
Sermorelin was first developed in the 1980s in the United States. Following the successful completion of clinical trials, it was approved in 1997 for the diagnosis and treatment of growth hormone deficiency in children. It was sold under the brand name, Geref. Later on, the FDA withdrew its approval in 2008 because of commercial reasons unrelated to its safety and efficacy. Since then, it has been discontinued by the manufacturer and is not available in the US.
Mechanism Of SERMORELIN 5MG
As a GHRH analog, it binds to growth hormone-releasing hormone receptors in the anterior pituitary gland. This, in turn, signals the body to produce and release more GH through somatotropic cells. Unlike the recombinant growth hormone, it doesn’t raise GH in the body to supraphysiological levels. In fact, it mimics the function of endogenous growth-releasing factor and increases the physiological secretion of GH to the maximum level.
Sermorelin exhibits cardioprotective effects. It has been shown to decrease cardiac remodeling and scarring following myocardial infarction. One study conducted on swine with ischemic cardiomyopathy found that GHRH analog reduced the size of infarct and improved diastolic strain. Furthermore, the activation of GHRH receptors initiated the signaling for the repairing process .
Similarly, another study reports that GHRH agonists can suppress inflammatory responses after a heart attack. Plus, these agents have the tendency to increase the number of blood vessels in the damaged area and reduce the death of cardiomyocytes. In short, sermorelin can improve the process of healing and cardiac remodeling through pathways involved in fibrosis, apoptosis and cardiac repair .
In the case of AIDS, the use of highly active antiretroviral therapy (HAART) has been shown to be associated with the development of lipodystrophy. It is an abnormal condition characterized by the uneven distribution of body fat. It may cause patient distress and lead to poor adherence to the therapy. Furthermore, low levels of growth hormones are observed in men with HIV lipodystrophy .
One study was conducted to test the hypothesis that GHRH analog can be used to treat/manage lipodystrophy in AIDS patients. 31 HIV men were recruited and randomized to receive either placebo or GHRH analog twice daily for 12 weeks. The results found that the treatment effectively increased the concentration of insulin-like growth factor-1. Plus, it also improved total and regional body composition, improved lean mass and reduced visceral fat. These findings indicate that GHRH agonists, including sermorelin, might potentially be a beneficial treatment strategy for HIV patients with lipodystrophy .
3. Antiaging Effects
The age-related changes are associated with a decrease in the levels of GH as people get older. GHRH analogs stimulate IGF-1 concentration and increase pituitary preserve. It also might be able to restore the neuroendocrine axis and promote youthful physiology in aging individuals .
One study involving elderly male and female participants was conducted to check the effect of GHRH analog on aging. Participants self-injected themselves with placebo for 4 weeks followed by a 16-week administration of a GHRH analog. The administration of the GHRH analog at night resulted in a rapid increase in growth hormone levels within 10 minutes, which was sustained for up to 2 hours. Additionally, the results revealed elevated levels of IGF-1 and IGFBP3, increased skin thickness, and an increase in lean body mass. Notably, improvements in insulin sensitivity and libido were observed in men, suggesting a more pronounced treatment effect on women .
4. Sleep Quality
Research shows that orexin, a neurochemical produced by the brain, plays an important role in the regulation of the sleep cycle. Studies show that sermorelin and other GHRH agonists can boost orexin levels, thus improving sleep quality . Furthermore, poor sleep is associated with age-related cognitive decline. The beneficial effects of GHRH analog, including sermorelin, on sleep might be because of its ability to enhance cognitive skills .
5. Growth Hormone Deficiency Disorder
Sermorelin produces the same effect as recombinant growth hormone. It builds muscle mass, boosts strength and enhances performance. However, sermorelin is preferred over recombinant growth hormone as it causes fewer side effects. It mimics the physiological process and is subjected to feedback mechanisms, thus preventing adverse effects like improper dosing and disruption of normal processes.
Furthermore, it is not affected by tachyphylaxis. It is a condition in which the body’s response to a drug is lost after repeated exposure and requires higher doses to achieve the desired effects .
Sermorelin is a GHRH analog that binds with growth hormone releasing-hormone receptors in the anterior pituitary gland. It stimulates the release of growth hormone and has been shown to reduce scaring and cardiac remodeling following myocardial infarction. Further, it has the potential to treat HIV-associated lipodystrophy, improve sleep quality and reverse age-related changes. It is no longer FDA-approved and is not available in the US market for therapeutic purposes. We don’t support its unwarranted use and offer sermorelin purchase exclusively for research. Only buy sermorelin if you are an authorized researcher.
- Bagno, L.L., et al., Growth hormone-releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy. J Am Heart Assoc, 2015. 4(4).
- Kanashiro-Takeuchi, R.M., et al., New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor. Oncotarget, 2015. 6(12): p. 9728-39.
- Bedimo, R., Growth hormone and tesamorelin in the management of HIV-associated lipodystrophy. HIV AIDS (Auckl), 2011. 3: p. 69-79.
- Koutkia, P., et al., Growth hormone-releasing hormone in HIV-infected men with lipodystrophy: a randomized controlled trial. Jama, 2004. 292(2): p. 210-8.
- Walker, R.F., Sermorelin: A better approach to the management of adult-onset growth hormone insufficiency? Clinical Interventions in Aging, 2006. 1(4): p. 307-308.
- Khorram, O., G.A. Laughlin, and S.S. Yen, Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women. J Clin Endocrinol Metab, 1997. 82(5): p. 1472-9..
- Shepherd, B.S., et al., Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2007. 146(3): p. 390-399.
- Benedict, C., C.D. Chapman, and H.B. Schiöth, Growth Hormone–Releasing Hormone Improves Cognitive Function in Older Adults: Sleep On It. JAMA Neurology, 2013. 70(4): p. 529-530.
Certificate of Analysis (COA)
High Performance Liquid Chromatography (HPLC)
What is Sermorelin?
A peptide called sermorelin, also known as GRF 1-29, has occasionally been studied for treating human growth hormone insufficiency. Sermorelin 5mg, which contains 29 amino acids, causes the adenohypophysis to release growth hormone. Based on how subjects responded when Sermorelin was administered intravenously, investigations on this peptide have been conducted. The participants in this study ranged in age from pre-puberty to adults. The findings supported a shift in children's growth patterns. A rise in growth hormone was indicative of the faster pace of growth. This shift in the pattern persisted for around three years. Sermorelin 5mg was tested in yet another research for the treatment of chronic renal failure. The study's participants ranged in age from 2 to 15 years. The primary goal of the study was to determine how this peptide affected patients with chronic renal failure's growth spurt. The trial only lasted between three and six months. The findings demonstrated that while sermorelin does speed up growth or spurts in people with chronic renal failure, it has no bearing on how quickly CRF advances. Structurally the composition of sermorelin is quite similar to CJC-1295 which is potent synthetic hormone. Growth hormone is a major entity that controls the growth and multiplication of various cells in the body. While we are young, the production of the growth hormone is at its peak. However, as the age advances, a steep fall in the level of growth hormone production has been noticed. With the regular use of Sermorelin 5mg, the levels of growth hormone production can be renewed via stimulation of the pituitary gland. Sermorelin is capable of enhancing the production of growth hormone which later gets converted into IGF-1 by liver. Furthermore, Sermorelin can be found augmenting the beneficial effects of IGF-1 too following its long-term usage. So, buy Sermorelin for research purposes to explore its potential applications in studying growth hormone regulation and related areas.
Research has been conducted on sermorelin, a synthetic peptide analog of growth hormone-releasing hormone (GHRH), in a number of disciplines, including endocrinology and anti-aging medicine. An overview of the research on sermorelin's mechanisms of action, possible therapeutic uses, and related clinical studies are covered in this page.
Mechanisms of Action
When sermorelin binds to particular receptors in the anterior pituitary gland, endogenous growth hormone (GH) is released. Sermorelin promotes a number of physiological effects, including improved protein synthesis, increased lean muscle mass, improved metabolism, and maybe anti-aging effects, by enhancing the generation and secretion of GH.
Potential Therapeutic Applications
Growth Hormone Deficiency:
Sermorelin is primarily used to identify and treat growth hormone deficiency (GHD), which affects both children and adults. Its effectiveness in raising GH levels in people with GHD has been shown in clinical research, which restores growth, improves body composition, and improves quality of life.
Anti-Aging and Wellness:
Due to its possible impacts on aging-related decline, sermorelin has drawn interest in the field of anti-aging medicine and wellness. According to several research, sermorelin administration may help older people feel more energised, operate better mentally, build stronger muscles, lose weight, and have better skin.
Growth Hormone Deficiency:
Sermorelin treatment in GHD patients has showed promising results in clinical trials. These studies show that in both children and people with GHD, growth metrics, body composition, bone density, and lipid profiles have improved.
Anti-Aging and Wellness:
While investigation into the anti-aging properties of sermorelin is underway, several studies have looked into its possible advantages. According to these studies, aging markers have improved, including lean muscle mass, obesity, athletic performance, and overall wellbeing.
Safety and Tolerability:
Sermorelin has been well tolerated in the majority of clinical trials, with minimal serious adverse effects documented. Investigations of sermorelin use's potential dangers and long-term safety data are ongoing.
Where to Buy Sermorelin
Sermorelin for sale is available for research purposes from the reputed internet vendor Pinnacle Peptides exclusively for researchers who are working on drudging on the potential of this peptide. Researchers can easily buy Sermorelin online at affordable prices from our website. Our website provides a convenient platform to purchase peptides, including Sermorelin, specifically for research applications. Sermorelin is normally categorized as a research chemical and should only be obtained by trained researchers with the appropriate authorization and adherence to legal and ethical requirements. This is vital to keep in mind. In order to guarantee product quality, dependability, and customer support when considering the purchase of Sermorelin or any other research peptide, it is crucial to ensure compliance with laws, adhere to institutional policies, and undertake careful supplier research.
The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.