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The chemicals/materials for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested.

What Is SARM's S4 ANDARINE 50MG / ML | 60ML?

Andarine, also known as S4, is a non-steroidal selective androgen receptor modulator (SARM). Research shows that its anabolic activity is similar to that of testosterone’s. It was initially discovered by a pharmaceutical company named GTx, Inc. for musculoskeletal disorders and benign prostatic hyperplasia. Later, it was found to improve fertility and sexual health in men and women. It has not been approved by the FDA yet. Further, it is banned by the World Anti-Doping Agency because of its misuse by athletes to enhance performance. At Pinnacle Peptides, S4 andarine for sale is exclusively available for research.

Structure Of SARM's S4 ANDARINE 50MG / ML | 60ML

From Pubchem


IUPAC Name: (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Synonyms: 401900-40-1, GTX-007, S-4 cpd
Molecular Formula: C19H18F3N3O6
Molecular Weight: 441.4 g/mol
CAS number: 401900-40-1
PubChem CID: 9824562

Mechanism Of SARM's S4 ANDARINE 50MG / ML | 60ML

As a SARM, andarine has been shown to target androgen receptors (AR) in selective tissues. It has been shown to affect receptors in bones and muscles without exerting any effect on prostate tissues. Research suggests that it is rapidly absorbed in the bloodstream after oral intake. It binds with high affinity (Ki=7.5 nM) to AR and exhibits agonist action. In bones, it has been shown to inhibit bone turnover, increase bone mineral density.

Pre-Clinical/Clinical Research

1. Fat Loss

S4 andarine has been shown to induce fat loss in animal models. One study was conducted to check the effect of andarine on fat loss in rats. The subjects were randomly administered S4 or placebo for 120 days. Researchers observed that the treatment group experienced a significant reduction in body fat as compared to the control group [1]. It is believed that the fat loss effect of this SARM might be related to the ability to increase muscle mass. The metabolic rate of the body increases with muscle mass, resulting in increased energy expenditure and fat utilisation.

2. Cancer

Literature reveals that Andarine might have the ability to inhibit tumor growth. The androgen receptor has been shown to be associated with the development of pancreatic cancer. Hence, SARMs might prove effective in treating pancreatic cancer. One study found that andarine suppressed growth and proliferation in pancreatic cancer cells through cell cycle arrest at the G0/G1 phase. It was observed to downregulate the expression of CDKN1A, a gene involved in regulating cell cycle and proliferation. Furthermore, it also found that the PI3/AKT/mTOR pathway is not involved in the carcinogenic effects of S4 on pancreatic cancer [2].

Similarly, andarine shows anticarcinogenic effects on lung cancer by inhibiting cell growth and proliferation and promoting apoptosis. Research suggests that it might suppress certain genes associated with antitumor activity [3]. Similarly, in the context of hepatocellular carcinoma (HCC), researchers found that Andarine inhibits HCC by targeting the PI3K/AKT/mTOR pathway, a frequently activated signaling pathway involved in the severity of HCC [4].

3. Muscle Mass

Literature supports the evidence that S4 can boost muscle mass and increase strength. In a study involving castrated male rats, researchers assessed the effects of S4 on skeletal muscles. The procedure of castration led to a reduction in androgen levels in the subjects. After twelve weeks of castration, the rats were administered either S4, testosterone, or a placebo. The treatment group exhibited a restoration in mass and strength of the soleus and levator ani muscles, comparable to levels in intact animals.

Furthermore, S4 had a minor impact (only 16 to 17%) on seminal vesicles as compared to dihydrotestosterone (50%). [5]. Another study found that Andarine S4 displayed selective activity by preferentially stimulating anabolic organs compared to androgenic tissues. Additionally, it revealed that the anabolic activity of S4 was similar to or greater than that of testosterone propionate [6].

4. Bone Mineral Density

Andarine positively impacts bone mineral density and might offer a promising treatment for osteoporosis. Estrogen levels decline with advancing age and contribute to bone weakness [7]

One study was conducted to check the impact of S4 on ovariectomized rats. These rats underwent a procedure for the removal of ovaries, that reduced estrogen levels in their body. Subsequently, they were treated with either placebo or andarine. The results found that the treatment group exhibited a significant improvement in bone mineral density and bone cortical quality. Furthermore, S4 was shown to increase the load-bearing capacity of the bone [8].


S4 is a selective androgen receptor modulator (SARM). It exerts anabolic effects in bone and muscle tissues with efficacy comparable to testosterone without affecting prostate tissues. It has been shown to induce weight loss, build mass and prevent bone loss. Furthermore, research suggests that it exhibits anticarcinogenic effects. It is often abused by athletes to enhance sports performance. However, further research is needed to validate these effects. We don’t encourage its unwarranted use and offer S4 andarine purchase exclusively for research. Only buy S4 andarine if you are a licensed researcher.


  1. Kearbey, J.D., et al., Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharm Res, 2007. 24(2): p. 328-35.
  2. Bölük, A., et al., In vitro anti-carcinogenic effect of andarine as a selective androgen receptor modulator on MIA-PaCa-2 cells by decreased proliferation and cell-cycle arrest at G0/G1 phase. Biochem Biophys Res Commun, 2023. 671: p. 132-139.
  3. Demircan, T., M. Yavuz, and A. Bölük, Andarine Plays a Robust In-vitro Anti-carcinogenic Role on A549 Cells Through Inhibition of Proliferation and Migration, and Activation of Cell-cycle Arrest, Senescence, and Apoptosis. 2023.
  4. Yavuz, M., L.S. Takanlou, B. Avcı Ç, and T. Demircan, A selective androgen receptor modulator, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling pathway. Gene, 2023. 869: p. 147390.
  5. Gao, W., et al., Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology, 2005. 146(11): p. 4887-97.
  6. Yin, D., et al., Pharmacodynamics of Selective Androgen Receptor Modulators. Journal of Pharmacology and Experimental Therapeutics, 2003. 304(3): p. 1334-1340.
  7. Kearbey, J.D., et al., Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharm Res, 2007. 24(2): p. 328-35.
  8. Kearbey, J.D., et al., Effects of selective androgen receptor modulator (SARM) treatment in osteopenic female rats. Pharm Res, 2009. 26(11): p. 2471-7.

Certificate of Analysis (COA)


High Performance Liquid Chromatography (HPLC)


What is S4 SARM?

S4 SARM, sometimes referred to as Andarine, is a selective androgen receptor modulator (SARM) that has been researched for possible uses in the areas of muscle building and athletic performance. S4 SARM primarily targets skeletal muscle tissue by selectively attaching to androgen receptors in the body. It is thought to improve protein synthesis and encourage the growth of muscles. Additionally, S4 SARM has demonstrated promise for enhancing bone health and possibly treating diseases that cause muscle wasting. It is crucial to remember that S4 SARM is only meant for research at this time and has not yet received approval for use in humans.

S4 SARM Research

A selective androgen receptor modulator (SARM) with the trade name Andarine, S4 SARM has gained interest in the scientific community. Studies have looked into its possible impacts on athletic performance, muscle growth, and therapeutic uses.

Mechanism of Action:

S4 SARM predominantly targets skeletal muscle tissue by binding to androgen receptors in the body. It binds to androgen receptors with a high affinity, which causes anabolic actions in muscle cells. S4 SARM is thought to boost protein synthesis, encourage muscle growth, and maybe enhance athletic performance by activating these receptors.

Muscle Building and Performance Enhancement:

The possible impact of S4 SARM in increasing muscle growth and improving athletic performance is a prominent topic of investigation. S4 SARM has been found in studies to increase lean muscle mass, strengthen muscles, and improve endurance. Due to its selective action, it may have less negative effects than conventional anabolic steroids while still having effects that are thought to be equivalent.

Muscle Wasting Conditions:

S4 SARM research has also looked into its possible therapeutic uses in disorders that cause muscle wastage. Early research on the treatment of muscle loss brought on by diseases like cancer cachexia and aging-related sarcopenia has yielded encouraging findings. In these people, S4 SARM might aid in maintaining strength and muscular mass, thus enhancing quality of life.

Bone Health:

Studies have looked into how the S4 SARM affects bone health. The benefits of S4 SARM on bone mineral density and bone strength may be advantageous in treating illnesses like osteoporosis or bone traumas, according to research. To completely comprehend its potential in enhancing bone health, more study is required.

Vision Changes:

The potential effects of S4 SARM on vision are a concern in the field of research. According to some research, people may have brief vision disturbances like a yellow tint or trouble adjusting to dim light. These outcomes are thought to be connected to the affinity of S4 SARM for specific retinal receptors. It's essential to comprehend and minimize these potential negative effects if you want to use S4 SARM safely.

Where to Buy S4 SARMS

If you looking to buy S4 SARMS online for research, you should only consider Pinnacle Peptides. We provide high-quality S4 SARMS that are ideal for scientific research with their trustworthy and respectable service. To assure purity and effectiveness, our products go through extensive testing. Pinnacle Peptides appreciates the value of accurate and trustworthy findings in research, which is why we offer top-notch SARMs to researchers. We may help you with your research whether it's related to fat loss, muscle gain, or other topics of interest. Put your faith in their knowledge and purchase your S4 SARMS from Pinnacle Peptides to advance your research. Researchers can contact the Pinnacle Peptides to buy S4 SARMS for less and in bulk quantities. However, S4 SARMS for sale here are not available for human consumption.


The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides and reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.

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DISCLAIMER: The products sold on this site are not a drug nor is it intended to treat, diagnose, cure or prevent any disease, nor is it meant for ANY cosmetic purpose. Pinnacle Peptides makes no claims of alleged beneficial properties of any product on this site if injected or ingested in any manner. Our Peptides are exclusively distributed legally within the laws of safe harbor for research peptides and are to be used for that purpose ONLY. If any country’s governing bodies feel we are in violation of their laws regarding peptides, we ask you contact us immediately via [email protected] so we may expeditiously rectify the situation.All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following:Their government regulations regarding the importation, purchase, possession and use of peptides. The health and safety hazards associated with the handling of peptides in a research setting. That peptides are NOT intended to be used as a food additive, drug, vitamin, supplement, cosmetic or any other inappropriate application. Such a sale would be otherwise denied.
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