What Is GW 501516 20MG/ML | 60ML?
GW-501516 is also referred to as cardarine or endurobol. It is frequently mistaken for SARM (selective androgen receptor modulator) despite having no effect on androgen receptors. In fact, it belongs to the class peroxisome proliferator-activated receptor agonist. Research shows that it increases fat loss, improves metabolic disorders and boosts strength performance. It has not been approved by the FDA yet. At Pinnacle Peptides, GW-501516 for sale is exclusively available for research and experimentation.
Structure Of GW 501516 20MG/ML | 60ML
IUPAC Name: 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
Synonyms: Endurobol, GW 1516
Molecular Formula: C21H18F3NO3S2
Molecular Weight: 453.5 g/mol
CAS number: 317318-70-0
PubChem CID: 9803963
Cardarine was initially developed by the collaboration of two medicinal companies named GSK and Ligand Pharmaceuticals in 1992. Later, GSK sponsored a phase I trial of cardarine for the treatment of hyperlipidemia in 2000, followed by phase I/II in 2002. By 2007, two phase II clinical trials of GW-501516 were completed but GSK abandoned the further development of the drug because of safety reasons.
Mechanism Of GW 501516 20MG/ML | 60ML
Cardarine is an agonist of the peroxisome proliferator-activated receptor delta (PPARδ). It displays high affinity and potency for PPARδ with 1000-fold selectivity over PPARα and PPARγ. PPAR are the receptors found in the nucleus that regulate genes involved in energy metabolism, cell differentiation and various other body processes. Research shows that GW-501516 activates AMP-activated protein kinase, and increases glucose uptake and fatty acid oxidation.
GW-501516 has been shown to improve diabetes and blood glucose levels through activation of AMP-activated protein kinase by PPAR-delta. AMPK is a signal that controls blood glucose levels and gets activated in the presence of low energy levels.
One study was designed to investigate the role of PPARδ agonists in gestational diabetes. Rat models of GDM were tested for fasting blood glucose levels, fasting insulin and insulin sensitivity index on days 3, 7 and 10. After that, their glucose tolerance test was performed on the 20th day of gestation. The findings indicated that treatment with cardarine improved blood glucose tolerance and insulin sensitivity. Furthermore, researchers observed an increased expression of GLUT-2 which is associated with cellular glucose uptake .
Furthermore, it has been proposed that peroxisome proliferator-activated receptor agonists might be able to improve diabetic wound healing. One study found that GW-501516 can accelerate wound healing in diabetic rats. Moreover, the researchers suggested that the activation of PPAR-delta stimulated the production of catalase and GPx1 (antioxidant enzymes). These enzymes then reduced the accumulation of H2O2, thus protecting the structure of the extracellular matrix in the wound area .
2. Fat loss
Activation of PPARδ has been shown to upregulate the expression of genes involved in beta-oxidation and energy dissipation. One study found that GW-501516 reduced hepatic fat content in overweight patients with mixed hyperlipidemia . Furthermore, it has been shown to increase HDL and decrease triglyceride levels as compared to the placebo. It also increases the expression of CPT1, CD36, and ABCA1, which suggests the increased utilization of peripheral fat .
PPARδ plays an important role in regulating inflammation and cancer. One study conducted on AOM/DDS-induced mice found that the use of GW-501516 was associated with colorectal cancer. The mechanism behind this carcinogenic effect is unclear. However, research shows that it increases the expression of GLUT1 and SLC1A5 in colon cancer cells and enhances the AOM/DDS-induced colorectal tumor. Furthermore, it has also been shown to increase the gene expression of pro-inflammatory cytokines in the inflamed colon .
4. Strength Performance
The use of cardarine is popular among the sports community as it is thought to enhance athletic performance. However, to date, there are no human studies available to confirm this effect. Only one study conducted on rats suggests that cardarine can improve strength performance .
GW-501516 is an agonist of the peroxisome proliferator-activated receptor delta that is found in the nucleus. It is involved in the expression of genes responsible for various bodily processes, including energy metabolism. It has been shown to increase fat loss, improve blood glucose control and speed up healing of wounds. Its use is associated with colorectal cancer, and it is not approved by the FDA for therapeutic use. We don’t support its unwarranted use and offer GW-501516 purchase exclusively for research. Only buy GW-501516 if you are a qualified researcher.
- Zhou, J., et al., The Role of PPARδ Agosnist GW501516 in Rats with Gestational Diabetes Mellitus. Diabetes, Metabolic Syndrome and Obesity, 2020. 13: p. 2307-2316.
- Wang, X., et al., Early controlled release of peroxisome proliferator-activated receptor β/δ agonist GW501516 improves diabetic wound healing through redox modulation of wound microenvironment. Journal of Controlled Release, 2015. 197: p. 138-147.
- Steensels, S., J. Qiao, and B.A. Ersoy, Transcriptional Regulation in Non-Alcoholic Fatty Liver Disease. Metabolites, 2020. 10(7): p. 283.
- Sprecher, D.L., et al., Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator-activated receptor delta agonist. Arterioscler Thromb Vasc Biol, 2007. 27(2): p. 359-65.
- Zhou, D., et al., PPARδ agonist enhances colitis-associated colorectal cancer. European Journal of Pharmacology, 2019. 842: p. 248-254.
- Chen, W., et al., A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice. Sci Rep, 2015. 5: p. 9884.
Certificate of Analysis (COA)
High Performance Liquid Chromatography (HPLC)
What is GW-501516?
Chemically speaking, GW-501516, also known as Cardarine, is a substance that falls under the category of medications known as selective androgen receptor modulators (SARMs). GW-501516, despite being marketed as a SARM, actually acts on a distinct cellular receptor called peroxisome proliferator-activated receptor delta (PPAR), not androgen receptors. The ability of GW-501516 to increase endurance and encourage fat burning is well documented. It functions by triggering PPAR, which in turn boosts the expression of genes involved in energy metabolism and enhances the use of fatty acids as fuel. This leads to increased aerobic capacity, increased stamina, and potential fat loss. Due to its performance-enhancing properties, GW-501516 has gained popularity among athletes and bodybuilders. However, it's important to note that GW-501516 is not approved for human use and its long-term effects on health and safety are still not well understood.
Due to its potential advantages in a number of areas, including the improvement of endurance and the regulation of metabolic process, GW-501516, also known as Cardarine, has been the focus of substantial research. A summary of the most important research findings on GW-501516 is presented in this section.
An important area of study has been on how GW-501516 affects endurance capacity. According to research conducted on animals, GW-501516 stimulates PPAR, which increases the expression of genes related to oxidative metabolism in skeletal muscle. This increase improves how well fatty acids are used as an energy source, increasing endurance. Studies on mice showing that GW-501516 treatment boosted running endurance have confirmed these findings.
It has also been researched how GW-501516 affects metabolism. According to research, GW-501516 can encourage the use of stored fat for energy and boost fatty acid oxidation. In animal models, it has been discovered to improve glucose metabolism and insulin sensitivity. Due to its favorable effects on metabolism, GW-501516 is a potential treatment option for obesity and other metabolic diseases.
The cardioprotective abilities of GW-501516 have been studied. Animal model studies have shown that the drug GW-501516 can guard against oxidative stress and cardiac inflammation. It has been shown to enhance heart function and lessen the development of plaque in blood vessels. These results imply that GW-501516 may be therapeutically useful in the management of cardiovascular disorders.
Safety and Side Effects:
Although preclinical research on GW-501516 showed positive results, its safety profile and potential negative effects have also been studied. There has been evidence of GW-501516 with cancer development in several animal trials. It is crucial to remember that these studies used incredibly high doses that go above and beyond normal levels of human exposure. To fully comprehend the long-term effects and potential hazards of GW-501516 in humans, more research is required.
Where to Buy GW-501516
Pinnacle Peptides offers GW-501516, also known as Cardarine, for purchase on their website. As a trusted supplier, we ensure the quality and authenticity of our products. Customers can conveniently browse our website and place an order for GW-501516 with ease. It is important to note that GW-501516 for sale is a research chemical and not intended for human consumption. Pinnacle Peptides emphasizes responsible and legal use of our products. Customers looking to buy GW-501516 online, can explore their selection and make a secure purchase. You can only buy buy GW-501516 if you intend to use them in your labs. Pinnacle Peptides supplies vials of this medicine for your research. You can select the amount and the number of vials that you require and have them delivered at your place. GW-501516 is very difficult to find in its purest form in the market. Most sellers will provide you with much diluted versions of it. This is why it is necessary that you buy it from the very best stores in the market. The online store of Pinnacle Peptides guarantees you only the best quality product that will serve you the best in your results. So order your vials today and can check out other sections of the store. All sorts of products that you might need while performing research can be picked up easily by logging in. The prices of these products are some of the best in the market. Pinnacle Peptides guarantees you good quality products within the best price ranges.
The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.