What Is T4 LEVOTHYROXINE 400MCGS / ML | 60ML?
Levothyroxine is a synthetic analog of the thyroid hormone, thyroxine (T4). It is an FDA-approved drug that is sold under the brand name synthroid. It is primarily indicated for the treatment of hypothyroidism, a condition in which the thyroid gland is unable to produce sufficient quantities of thyroxine (T4 or tetraiodothyronine).
Plus, it can also be used in combination with surgery and radiation therapy to address thyroid cancer. Currently, it is being researched for its effect on multiple sclerosis and non-alcoholic fatty liver disease (NAFLD). At Pinnacle Peptides, levothyroxine for sale is exclusively available for research and educational institutions.
Structure Of T4 LEVOTHYROXINE 400MCGS / ML | 60ML
IUPAC Name: (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl] propanoic acid
Synonyms: L-thyroxine, levothyroxin, 51-48-9, thyroxine, thyroxin
Molecular Formula: C15H11I4NO4
Molecular Weight: 776.87 g/mol
CAS number: 51-48-9
PubChem CID: 5819
Mechanism Of T4 LEVOTHYROXINE 400MCGS / ML | 60ML
Levothyroxine mimics the function of thyroxine (T4), an endogenous hormone produced by the thyroid gland. After it is absorbed by the gastrointestinal tract, it undergoes a transformation in liver cells and is converted to its active form, L-triiodothyronine (T3). T3, in turn, binds to thyroid receptors located in the cell nucleus. This, in turn, activates downstream signaling that influences gene expression and protein synthesis, leading to enhanced metabolic effects, such as increased thermogenesis and oxygen consumption.
1. Congenital Hypothyroidism
Congenital hypothyroidism is characterized by a deficiency of thyroid hormone in newborns. It is a fatal condition that requires prompt diagnosis to prevent irreversible neurological damage. Research suggests that immediate treatment of levothyroxine (L-T4) upon diagnosis, preferably within the first two weeks after birth, successfully reduces the risk of intellectual deficits and optimizes neurodevelopment .
Furthermore, T4 is considered a preferred treatment for congenital hypothyroidism . One study concluded that combination treatment with T4 plus T3 didn’t show any significant advantage over T4 therapy in patients with congenital hypothyroidism .
The effective treatment of congenital hypothyroidism typically involves a single morning dose of oral levothyroxine. However, an initial study in adult patients suggested that levothyroxine administration in the evening might yield at least an equal, if not better, therapeutic effect compared to morning administration .
2. Polycystic ovary syndrome (PCOS)
According to the guidelines of the American Thyroid Association, hypothyroid women aiming for pregnancy should modify their levothyroxine dosage to attain a TSH level within the range of the lower reference limit and 2.5 mIU/L. However, there is insufficient evidence to establish whether levothyroxine supplementation enhances fertility in anti-TPO antibody-positive women with subclinical hypothyroidism who are trying to conceive naturally .
In a small case-control study, levothyroxine treatment in women with polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) demonstrated no significant impact based on multivariate analysis. The T4 treatment did not alter serum metabolic markers, including LDL and HDL cholesterol, triglycerides, glucose, and insulin .
3. Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune disease characterized by the demyelination of nerves. Stats show that approximately 70% of individuals with MS experience impaired and demyelinated visual systems. Oligodendrocyte progenitor cells (OPC) play an important role in the generation of oligodendrocytes, which are responsible for the myelination of nerve fibers. Research shows that the effectiveness of this process depends on various factors including thyroid hormones .
According to one study in male Wistar rats’, intraperitoneal administration of levothyroxine at doses of 50 and 100 μg/kg effectively prevented impairments in visual evoked potentials induced by lysolecithin. However, the lower levothyroxine dose (20 μg/kg) did not exhibit any effects . These findings suggest that higher doses of thyroid hormones have more favorable effects on the healing process following demyelination induced by lysolecithin injection.
4. Nonalcoholic Fatty Liver Disease (NAFLD)
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of extrahepatic fat in the absence of excessive alcohol consumption. The rising prevalence of NAFLD is contributing to a growing need for liver transplantation. As levothyroxine has been shown to reduce body weight and serum lipid levels, it might alleviate the negative side effects of NAFLD.
One study found that levothyroxine replacement therapy had a positive impact on NAFLD patients with subclinical hypothyroidism (SCH). It reduced the prevalence of NAFLD and lowered hepatic enzyme levels in serum. The results of the study suggest that thyroxine supplementation could be an effective treatment to manage NAFLD in patients with SCH .
Levothyroxine is a synthetic levo-isomer analog of the thyroxine hormone produced by the thyroid gland. Researchers show that it is an effective drug for the treatment of hypothyroidism, multiple sclerosis and nonalcoholic fatty liver disease. Despite being FDA-approved, it is still being tested to determine its efficacy in other clinical conditions. At Pinnacle Peptides, we offer levothyroxine purchase solely for research. Only buy levothyroxine if you are a qualified researcher.
- Rousset, B., et al., Thyroid hormone synthesis and secretion. 2015.
- Goldis., S.A.B.M. Congenital Hypothyroidism. 2023; Available from:
- Bernal, J., Thyroid hormones and brain development. Vitamins & Hormones, 2005. 71: p. 95-122.
- Cassio, A., et al., Treatment for congenital hypothyroidism: thyroxine alone or thyroxine plus triiodothyronine? Pediatrics, 2003. 111(5): p. 1055-1060.
- Bolk, N., et al., Effects of evening vs morning thyroxine ingestion on serum thyroid hormone profiles in hypothyroid patients. Clinical endocrinology, 2007. 66(1): p. 43-48.
- Alexander, E.K., et al., 2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid, 2017. 27(3): p. 315-389.
- Kowalczyk, K., et al., The influence of treated and untreated subclinical hypothyroidism on metabolic profile in women with polycystic ovary syndrome. International Journal of Endocrinology, 2021. 2021.
- Calzà, L., M. Fernandez, and L. Giardino, Cellular approaches to central nervous system remyelination stimulation: thyroid hormone to promote myelin repair via endogenous stem and precursor cells. Journal of molecular endocrinology, 2009. 44(1): p. 13-23.
- Payghani, C., et al., Effects of levothyroxine on visual evoked potential impairment following local injections of lysolecithin into the rat optic chiasm. International Journal of Preventive Medicine, 2018. 9.
- Zhao, M., et al., A worthy finding: decrease in total cholesterol and low-density lipoprotein cholesterol in treated mild subclinical hypothyroidism. Thyroid, 2016. 26(8): p. 1019-1029.
- Liu, L., et al., Benefits of levothyroxine replacement therapy on nonalcoholic fatty liver disease in subclinical hypothyroidism patients. International Journal of Endocrinology, 2017. 2017.
What is T4 Levothyroxine?
T4 Levothyroxine is a synthetic version of the thyroid hormone thyroxine, also referred to as Levothyroxine or T4. People with hypothyroidism, a condition marked by an underactive thyroid gland, are frequently administered medication. By replenishing the body's deficient thyroid hormone production, T4 Levothyroxine aids in reestablishing hormonal balance. Other thyroid conditions including goiter and thyroid cancer are managed with it as well. T4 Levothyroxine helps control metabolism, energy production, and numerous body processes by raising thyroid hormone levels. To maintain adequate dosing and monitoring, it is essential to take T4 Levothyroxine as advised by a healthcare provider. For the production of T3 and T4, Iodine is essential. When there is a deficiency of Iodine, it leads to decreased production of T3 and T4, which in turn causes the disease called goiter. The functions of this peptide hormone includes activities like increase in basal metabolic rate, affecting protein synthesis, regulate bone growth, proper development and differentiation of all cells, regulate protein, fat, and carbohydrate and vitamin metabolism etc. It also leads to heat generation in humans.
T4 Levothyroxine Research
T4 Levothyroxine is a synthetic version of the thyroid hormone thyroxine, also referred to as Levothyroxine or T4. T4 Levothyroxine has been the subject of extensive research with the goal of enhancing therapeutic strategies, comprehending its mechanisms of action, and investigating potential novel uses. The usage of T4 Levothyroxine in various thyroid hormone treatment modalities is highlighted below:
Treatment of Hypothyroidism:
The use of T4 Levothyroxine in the management of hypothyroidism, a disorder defined by an underactive thyroid gland, is a major area of study. Studies seek to establish the ideal delivery schedules, dose regimens, and monitoring standards for thyroid hormone replacement therapy. The effects of T4 Levothyroxine on symptoms, quality of life, and long-term results in people with hypothyroidism are the subject of research.
Management of Thyroid Cancer:
T4 Levothyroxine research also examines the management of thyroid cancer as a potential application. Patients frequently need T4 Levothyroxine as a lifelong replacement therapy after a thyroidectomy or radioactive iodine therapy. Studies look into how T4 Levothyroxine affects tumor recurrence rates, survival rates, and the general well-being of patients. Researchers want to develop guidelines for long-term care of thyroid cancer patients and optimize dosing regimens.
Children and pregnant women are two specific populations that are the subject of T4 Levothyroxine research. Studies look at how T4 Levothyroxine affects the health of the mother and fetus as well as the neurodevelopmental consequences for kids born to mothers with thyroid disorders. These studies advance knowledge of the best dosing approaches and emphasize the value of maintaining a healthy thyroid hormone balance during pregnancy and infancy.
Treatment Monitoring and Individualized Approaches:
Monitoring thyroid hormone levels when taking T4 Levothyroxine is another area of research. Studies are being conducted to establish the ideal target range for thyroid-stimulating hormone (TSH) levels as well as to investigate tailored dosing strategies depending on variables like age, comorbidities, and drug interactions. Researchers work to enhance patient outcomes and reduce potential negative effects by customizing therapy regimens to individual needs.
Emerging Areas of Investigation:
Beyond its conventional uses, T4 Levothyroxine research is now focusing on its possible effects on cardiovascular health, cognitive function, and quality of life. Initial research focuses on its impacts on blood pressure and lipid profiles, two cardiovascular risk factors. In order to clarify the function of T4 Levothyroxine in maintaining cognitive health, research also explores the connection between thyroid function and cognitive decline.
Where to Buy T4 Levothyroxine
Pinnacle Peptides is a trusted supplier to buy T4 online for all your research ventures. Don’t settle for anything less than 99% pure peptides. With Pinnacle Peptides, you’re always ensured of the highest quality T4 at all times. When you buy T4 for research activities, make sure to procure it from a reliable supplier source. We strive to offer nothing but the best to the customers. High quality and purity of the research supply is essential to conduct researches which lead to accurate results. Contaminations may result in reducing the quality of the research. We are an online peptide suppliers who offers high quality products at attractive prices along with additional facilities. These facilities may include domestic and international shipping services etc. It is important to note that T4 for sale here is not for human consumption. Do not use these products for any other purpose other than research activities. It is not suitable for direct human consumption. Have a look at our online inventory to purchase T4 or other products and fill all your research supplies.
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