What Is T3 LIOTHYRONINE 200MCG / ML | 60ML?
Liothyronine is a man-made thyroid hormone, triiodothyronine (T3). It has been available in the market since the 1950s. As an FDA-approved drug, it is indicated for thyroid replacement therapy in hypothyroidism. It is a condition in which the thyroid gland is unable to produce sufficient levels of T3 and T4 (thyroxine). Thyroid hormones play a critical role in the regulation of various physiological processes and disruption in their levels is associated with various conditions like cognitive impairment, heat intolerance and infertility.
Liothyronine has been studied extensively by scientists. It has been shown to positively affect thyroid cancer, boost fertility and improve mental health disorders. Research shows that it has a better safety and pharmacokinetic profile as compared to levothyroxine (T4). At Pinnacle Peptides, liothyronine for sale is exclusively available for research and educational institutions.
Structure Of T3 LIOTHYRONINE 200MCG / ML | 60ML
IUPAC Name: (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
Synonyms: 3,3',5-Triiodo-L-thyronine, 6893-02-3, Tresitope
Molecular Formula: C15H12I3NO4
Molecular Weight: 650.97 g/mol
CAS number: 15785-49-6
PubChem CID: 5920
Mechanism Of T3 LIOTHYRONINE 200MCG / ML | 60ML
Liothyronine mimics the endogenous function of the thyroid hormone, T3. It acts on the thyroid receptors (TR) present in the nucleus of a cell, specifically bound to DNA. The activated TR then binds to the specific sequence of DNA called the thyroid response element located in the promoter region. This, in turn, influences the transcription of DNA, either enhancing or suppressing the expression of genes, thus affecting protein synthesis. Studies show that Liothyronine exerts similar effects as endogenous thyroid hormones. It has been shown to increase energy expenditure, accelerate cellular oxidation and boost the metabolism of carbohydrates and protein .
Infertility is one of the most significant complications of hypothyroidism. It can disrupt the normal reproductive cycle and ovulation process. Bringing the thyroid hormone levels back to normal might help infertile women conceive. In one study, 38 women with fertility issues were treated with liothyronine sodium therapy. The results found that treatment normalized the ovulation pattern and menstrual cycle in 10 women. Furthermore, 14 of the participants in the study were able to conceive within six months of therapy .
Similarly, one study on men found that the t4 hormone administration improved the quality and quantity of active sperm in men. However, we need further research to confirm the effectiveness of thyroid hormone therapy in treating male infertility .
2. Multiple Sclerosis
Multiple sclerosis is an autoimmune disorder that affects the myelination of nerve fibers. Thyroid hormones have shown the potential to support remyelination in animal models of MS. Research suggests that triiodothyronine (T3) plays a crucial role in promoting the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes that are responsible for myelination of fibers.
In the initial phase one randomized controlled trial that involved six patients with multiple sclerosis, participants were randomly assigned to receive either a placebo or liothyronine. The findings revealed that the short-term use of liothyronine was safe and well-tolerated, with a maximum tolerated dose identified as 75 mcg total daily dose .
Building upon these promising results, a subsequent phase Ib clinical trial was conducted. It replicated the results and proved the safety and tolerability of T3 in individuals with multiple sclerosis. Moreover, researchers observed proteomic changes in cerebrospinal fluid (CSF), indicating that triodothyronine also influences physiological processes in the central nervous system .
These findings suggest the potential use of liothyronine as a potential treatment for MS to reverse nerve damage. Further exploration of T3 might lead to the development of novel therapy for the management of multiple sclerosis.
Levothyroxine and liothyronine are FDA-approved drugs for the treatment of hypothyroidism. These drugs have been shown to effectively manage symptoms associated with the disorder. In a study, combination therapy of T3 and T4 normalized thyroid-stimulating hormone levels in 88.74 % of the participants. The treatment improved patients' quality of life without causing serious side effects associated with the therapy .
The addition of Liothyronine to the regimen is associated with positive outcomes in depression patients. Research suggests that T3 shows some activity at the serotonergic, dopaminergic and beta-adrenergic receptors and might behave like a neurotransmitter. Plus, it has been shown to support the formation of neurons .
One study indicated that Liothyronine can be used with other antidepressants, such as tricyclic antidepressants, to improve the quality of life in patients with unipolar depression. However, we need long-term studies to prove its efficacy .
5. Weight Loss
Triiodothyronine (T3) can boost metabolic rate which results in increased energy expenditure and subsequent weight loss. In a randomized double-blinded cross-over study involving individuals aged 70 years or above with subclinical hypothyroidism, both T3 and T4 were administered. The findings revealed that participants who received T4 experienced a weight loss of 1.1 kg, while those on T3 demonstrated a more significant weight loss of 2.5 kg. Additionally, the T3 group exhibited a greater reduction in fat mass, with an average decrease of 1.5 kg, compared to the T4 group's 0.7 kg reduction .
Another study aimed to assess the effectiveness of thyroid hormone replacement therapy using either levothyroxine or liothyronine. Fourteen subjects who participated in the study were treated with T3 or T4 three times a day for 6 weeks. The results indicated that T3 supplementation resulted in more pronounced weight loss .
T3 Liothyronine is a synthetic version of thyroid hormone. It is used for the treatment of hypothyroidism. Furthermore, it has been shown to boost fat loss, improve multiple sclerosis and treat infertility. Research shows it exerts some action at dopamine and serotonin receptors and might improve the quality of life in patients with depression. However, we need more studies to establish its efficacy in treating these conditions. We don’t support its unwarranted clinical use and offer T3 liothyronine purchase exclusively for research. Only buy T3 liothyronine if you are a qualified researcher.
- Hassler, F.S., Liothyronine Therapy in Female Infertility. Fertility and Sterility, 1958. 9(6): p. 555-559.
- Farris, E.J. and S.W. Colton, Effects of L-Thyroxine and Liothyroxine on Spermatogenesis. Journal of Urology, 1958. 79(5): p. 863-867.
- Wooliscroft, L., et al., Phase I randomized trial of liothyronine for remyelination in multiple sclerosis: A dose-ranging study with assessment of reliability of visual outcomes. Multiple Sclerosis and Related Disorders, 2020. 41: p. 102015.
- Newsome, S.D., et al., A Phase 1b, Open-Label Study to Evaluate the Safety and Tolerability of the Putative Remyelinating Agent, Liothyronine, in Individuals with MS. Neurotherapeutics, 2023.
- Tariq, A., et al., Effects of Long-Term Combination LT4 and LT3 Therapy for Improving Hypothyroidism and Overall Quality of Life. South Med J, 2018. 111(6): p. 363-369.
- Lisa J. Rosenthal, M.D. ,, Whitney S. Goldner, M.D. , and, and John P. O'Reardon, M.D., T3 Augmentation in Major Depressive Disorder: Safety Considerations. American Journal of Psychiatry, 2011. 168(10): p. 1035-1040.
- Touma, K.T.B., A.M. Zoucha, and J.R. Scarff, Liothyronine for Depression: A Review and Guidance for Safety Monitoring. Innov Clin Neurosci, 2017. 14(3-4): p. 24-29.
- P, M., et al., - Physiologic Effects of Levothyroxine and Liothyronine in the in Older Individuals. J Endocr Soc, 2021. 5(Suppl 1).
- Celi, F.S., et al., Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine. J Clin Endocrinol Metab, 2011. 96(11): p. 3466-74.
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